Fig. 2

2ccPA did not interfere with the upregulation of LPA-driven profibrotic markers in SSc skin fibroblasts. SSc skin fibroblasts (n = 5) were incubated with 30 μM LPA in the presence or absence of 10 μM 2ccPA for 6 h. The expression of COL1A1, COL1A2, CTGF, and IL-6 mRNA were determined by qPCR. Data are the representative of three independent experiments. The bars represent as median with IQR. *p < 0.05