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Table 3 Number and proportions of patients with OI ≥ 2-fold increase at week 5 in PCV-13 serotypes by subgroup

From: Evaluation of pneumococcal and tetanus vaccine responses in patients with rheumatoid arthritis receiving baricitinib: results from a long-term extension trial substudy

 

Serotype 4

Serotype 6B

Serotype 14

Serotype 23F

Overall baricitinib group (N = 106)

74 (76)

76 (76)

47 (47)

73 (73)

Concomitant corticosteroids

 Yes (N = 31)

27 (87)

26 (84)

14 (45)

20 (65)

 No (N = 72)

47 (70)

50 (72)

33 (48)

53 (77)

Age group

 Patients < 65 years (N = 80)

61 (81)

66 (86)

40 (52)

58 (75)

 Patients ≥ 65 years (N = 23)

13 (57)

10 (43)

7 (30)

15 (65)

SDAI prior to vaccination

 ≤ 3.3 (N = 21)

14 (70)

16 (76)

11 (52)

16 (76)

 > 3.3 and ≤ 11 (N = 47)

36 (82)

34 (76)

24 (53)

29 (64)

 > 11 (N = 32)

23 (74)

25 (81)

11 (35)

26 (84)

Dose

 2 mg (N = 16)

11 (73)

11 (73)

9 (60)

9 (60)

 4 mg (N = 87)

63 (76)

65 (76)

38 (45)

64 (75)

  1. Data are reported as n (%)
  2. OI opsonization index, PCV-13 13-serotype pneumococcal conjugate vaccine, SDAI Simple Disease Activity Index