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Table 4 Diagnostic accuracy of LUS in different LIS

From: A simplified lung ultrasound for the diagnosis of interstitial lung disease in connective tissue disease: a meta-analysis

Different LIS

Study no.

Number

Sensitivity (95% CI)

Heterogeneity

Specificity (95% CI)

Heterogeneity

PLR (95% CI)

NLR (95% CI)

DOR (95% CI)

AUC (SE)

Q* (SE)

ILD (+)

ILD (−)

I 2

p value

I 2

p value

Total

11

266

221

0.859 (0.812–0.898)

62.8

0.001

0.839 (0.782–0.886)

68.1

0

5.412 (3.026–9.680)

0.176 (0.111–0.279)

43.16 (22.58–82.52)

0.934 (0.017)

0.871 (0.021)

All

4

68

105

0.955 (0.873–0.991)

0

0.721

0.876 (0.798–0.932)

59.6

0

5.476 (2.597–11.55)

0.086 (0.035–0.211)

59.76 (21.05–1525.8)

0.975 (0.016)

0.927 (0.027)

72

2

49

48

0.814 (0.691–0.903)

35.0

0.215

0.358 (0.486–0.804)

92.2

0

3.367 (1.810–6.621)

0.208 (0.110–0.396)

25.57 (5.183–146.7)

–

–

65

1

16

11

0.75 (0.48–0.93)

–

–

0.82 (0.48–0.98)

–

–

4.13 (1.14–14.91)

0.31 (0.13–0.75)

13.50 (2.01–90.69)

–

–

50

1

26

8

1.000 (0.398–1.000)

–

–

1.000 (0.158–1.000)

–

–

5.400 (0.423–68.96)

0.120 (0.008–1.746)

45.00 (0.666–3042.6)

–

–

14

2

56

32

0.982 (0.904–1.000)

32.4

0.224

0.875 (0.710–0.965)

0

0.485

7.297 (3.050–17.45)

0.029 (0.006–0.147)

292.30 (35.53–2403.8)

–

–

10

1

53

17

0.736 (0.597–0.847)

–

–

0.882 (0.636–0.985)

–

–

6.255 (1.685–23.223)

0.299 (0.185–0.485)

20.893 (4.232–103.15)

–

–

  1. The number 1 means 100% in sensitivity and specificity
  2. LIS intercostal spaces, ILD interstitial lung disease, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic OR, AUC area under the curve, CI confidence interval, SE standard error, − not available