A simplified lung ultrasound for the diagnosis of interstitial lung disease in connective tissue disease: a meta-analysis

Table 5 Summary diagnostic accuracy of LUS in different diseases

Disease	Study no.	Numbers		Sensitivity (95% CI)	Heterogeneity		Specificity (95% CI)	Heterogeneity		PLR (95% CI)	NLR (95% CI)	DOR (95% CI)	AUC (SE)	Q* (SE)
Disease	Study no.	ILD (+)	ILD (−)	Sensitivity (95% CI)	I ²	p value	Specificity (95% CI)	I ²	p value	PLR (95% CI)	NLR (95% CI)	DOR (95% CI)	AUC (SE)	Q* (SE)
SSc	6	170	87	0.839 (0.777–0.889)	78.3	0	0.870 (0.774–0.936)	21.4	0.272	6.203 (3.565–10.800)	0.191 (0.098–0.373)	42.93 (17.75–103.79)	0.929 (0.024)	0.864 (0.029)
RA	3	37	91	0.946 (0.818–0.993)	0	0.636	0.824 (0.730–0.896)	91.8	0	7.398 (0.768–74.220)	0.082 (0.024–0.275)	80.24 (8.107–796.09)	0.9810 (0.014)	0.939 (0.027)

CTD connective tissue disease, ILD interstitial lung disease, SSc systemic sclerosis, RA rheumatoid arthritis, PLR positive likelihood ratio, NLR negative likelihood ratio, DOR diagnostic OR, AUC area under the curve, CI confidence interval, SE standard error, − not available