Table 3 Top 20 most significantly overrepresented biological process gene ontology terms in downregulated differentially expressed genes when comparing mesenchymal stem cells (MSCs) exposed to activated peripheral blood mononuclear cells (PBMCs) from rheumatoid arthritis (RA) patients with MSCs exposed to resting PBMCs from RA patients

GO:0030198

Extracellular matrix organization

2.51E−11

7.88E−08

GO:0043062

Extracellular structure organization

2.51E−11

7.88E−08

GO:0032501

Multicellular organismal process

1.65E−10

4.44E−07

GO:0007275

Multicellular organism development

3.75E−10

7.84E−07

GO:0001501

Skeletal system development

8.09E−10

1.52E−06

GO:0044707

Single-multicellular organism process

1.51E−09

2.36E−06

GO:0048731

System development

1.77E−09

2.37E−06

GO:0009888

Tissue development

2.54E−09

3.19E−06

GO:0048856

Anatomical structure development

3.40E−09

4.00E−06

GO:0003008

System process

4.52E−09

5.00E−06

GO:0032502

Developmental process

7.01E−09

7.33E−06

GO:0044767

Single-organism developmental process

1.47E−08

1.46E−05

GO:0007155

Cell adhesion

2.26E−08

2.09E−05

GO:0022610

Biological adhesion

2.47E−08

2.09E−05

GO:0022617

Extracellular matrix disassembly

8.97E−08

6.49E−05

GO:0048513

Animal organ development

1.20E−07

8.39E−05

GO:0030574

Collagen catabolic process

2.43E−07

1.63E−04

GO:0044243

Multicellular organism catabolic process

4.05E−07

2.54E−04

GO:0009653

Anatomical structure morphogenesis

6.10E−07

3.59E−04

GO:0009887

Organ morphogenesis

1.76E−06

9.74E−04