Symptomatic bone marrow lesions induced by reduced bone mineral density in middle-aged women: a cross-sectional Japanese population study

Table 6 Relationships between BMLs and bone markers in participants with symptomatic knee

With symptomatic knee (n = 68)	R² (adjusted)	β	p value	95% CI
BAP	0.239	0.314	0.006	0.004 to 0.024
PINP	0.198	0.231	0.043	0.000 to 0.005
NTx	0.189	0.210	0.065	0.000 to 0.013
TRACP-5b	0.188	0.225	0.068	0.000 to 0.000
Pentosidine	0.151	− 0.084	0.482	− 0.008 to 0.004
Homocysteine	0.152	− 0.093	0.440	− 0.025 to 0.011

Statistical analysis—multiple linear regression analysis. Dependent variables—the natural logs of BML score plus 5. Independent variables—age, BMI, and bone markers (BAP, PINP, NTx, TRACP-5b, pentosidine, and homocysteine)
BMLs bone marrow lesions, BAP bone-specific alkaline phosphatase, PINP procollagen type I N-terminal propeptide, NTx crosslinked N-telopeptide of type I collagen, TRACP-5b tartrate-resistant acid phosphatase-5b, R² coefficient of determination, β standardized regression coefficient, CI confidence interval

ISSN: 1478-6362