Skip to main content

Table 1 Baseline characteristics of all RA patients and of subgroups of ACPA-positive and ACPA-negative patients

From: ACPA-negative RA consists of subgroups: patients with high likelihood of achieving sustained DMARD-free remission can be identified by serological markers at disease presentation

 

All RA patients (n = 299)

ACPA-positive RA patients (n = 158)

ACPA-negative RA patients (n = 141)

Age in years, mean (SD)

57 (14)

54 (14)

60 (14)

Female, n (%)

198 (66)

105 (66)

93 (66)

Symptom duration in weeks, median (IQR)

15 (8–32)

18 (9–38)

12 (5–26)

(Sub)acute symptom onset, n (%)

95 (34)

39 (27)

56 (43)

66-SJC, median (IQR)

6 (3–11)

5 (2–8)

8 (3–12)

68-TJC, median (IQR)

9 (4–15)

7 (4–13)

10 (4–18)

RF positivity, n (%)

183 (61)

134 (85)

49 (35)

ESR (mm/h), median (IQR)

28 (14–41)

28 (14–41)

28 (11–41)

CRP (μg/mL), median (IQR)

10 (3–23)

8 (3–18)

12 (3–30)

PTGA (0–100), median (IQR)

70 (50–80)

70 (45–80)

70 (60–80)

DAS44, median (IQR)

2.9 (2.4–3.4)

2.8 (2.3–3.3)

3.0 (2.5–3.7)

MBDA category

 Low (< 30), n (%)

43 (14)

26 (16)

17 (12)

 Moderate (30–44), n (%)

64 (21)

35 (22)

29 (21)

 High (> 44), n (%)

192 (64)

97 (61)

95 (67)

  1. Some data were missing as follows: symptom duration n = 4, (sub)acute symptom onset n = 23, 66-SJC n = 19, 68-TJC n = 17, ESR n = 3, PTGA n = 50 , DAS44 n = 20 and CRP n = 1
  2. Symptom duration, time between symptom onset and inclusion in cohort; (sub)acute symptom onset, prompt onset of symptoms (< 1 week); SD, standard deviation; IQR, interquartile range; SJC, 66-swollen joint count; TJC, 68-tender joint count; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; PTGA, patient global assessment; DAS, disease activity score; RF, rheumatoid factor; ACPA, anti-citrullinated protein antibodies; RA, rheumatoid arthritis; MBDA, multi-biomarker disease activity