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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: The RIG-I pathway is involved in peripheral T cell lymphopenia in patients with dermatomyositis

Fig. 4

RIG-I overexpression and pppRNA activation induced apoptosis and reduced the viability of Jurkat cells. a A significant increase of apoptotic populations (annexin V+/7-AAD−) was observed with pppRNA 12 h and 24 h activation or RIG-I overexpression. b The proliferation of Jurkat cells was inhibited significantly after pppRNA 12 h and 24 h activation or RIG-I overexpression. c RIG-I protein expression was upregulated in Jurkat cell and the elevated expressions of Fas and caspase 3 increased after pppRNA 12 h and 24 h activation or RIG-I overexpression. The relative intensity values were measured with ImageJ software, and the results are shown below the blot. The Western blot analysis was performed at least two times, and representative results are shown. *p ≤ 0.05

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