Fig. 1

Patient disposition. †The primary reason for not completing screening phase included: inclusion/exclusion criteria not fulfilled (n = 169), withdrawal of consent (n = 12), adverse event (n = 1), lost to follow-up (n = 1), and other (n = 8); *Four patients in each treatment group were not eligible for TP2; 2 patients in each treatment group were eligible but did not enter TP2; ETN, reference etanercept; SDZ ETN, Sandoz etanercept; TP, treatment period