Skip to main content

Advertisement

Table 1 Baseline characteristics of patients with “seronegative” and “seropositive” early arthritis (n = 748)

From: Outcome of patients with early arthritis without rheumatoid factor and ACPA and predictors of rheumatoid arthritis in the ESPOIR cohort

  Seronegative
(n = 354)
Seropositive
(n = 394)
P value**
Female, n (%) 274 (77.4%) 305 (77.4%) 0.997
Age (years), mean (SD) 48.9 (13.2) 47.7 (11.9) 0.058
Caucasian, n (%) 330 (93.2%) 359 (91.1%) 0.287
Current tobacco exposure, n (%) 173 (48.9%) 187 (47.5%) 0.700
Current alcohol consumption, n (%) 61 (17.2%) 71 (18%) 0.778
Symptom duration at first visit (months), mean (SD) 3.4 (1.7) 3.4 (1.8) 0.693
Morning stiffness (min), mean (SD) 75.6 (144.6) 110.1 (214.8) 0.008
Pain at rest (VAS, 0–100), mean (SD) 37.2/100 (27.6) 38/100 (27.5) 0.684
TJC, mean (SD) 8.8 (7.2) 8.3 (6.9) 0.521
SJC, mean (SD) 7.1 (5.5) 7.6 (5.4) 0.077
Extra-articular manifestations ♯ 188/346 (54.3%) 191/383 (52.5%) 0.228
Anti-CCP positive, n (%) 0 325 (82.5%)
Anti-CCP, units/ml mean (SD) 0.2 (1.3) 292.3 (201.7) < 0.001
IgM-RF positive, n (%) 0 358 (90.9%)
IgM-RF, IU/ml, mean (SD) 4.6 (1.5) 238.5 (770.8) < 0.001
ANA positive, n (%) 45 (12.8%) 111 (28.5%) < 0.001
ESR, mm/h, mean (SD) 25.8 (23.3) 32.9 (24.8) < 0.001
CRP level, mg/L mean (SD) 18.3 (33.1) 21.9 (30.6) < 0.001
DAS28, mean (SD) 5.0 (1.3) 5.3 (1.3) 0.002
HAQ-DI, mean (SD) 0.9 (0.7) 1 (0.7) 0.030
mTSS, mean (SD) 4.3 (6) 5.7 (8.2) 0.026
HLA-DRΒ1*01 or 04 gene, n (%) 112 (31.6%) 241 (61.2%) < 0.001
HLA-DRΒ1*03 gene, n (%) 77 (21.8%) 60 (15.2%) 0.021
2010 ACR/EULAR criteria (≥ 6/10 points), n (%) 224/340 (65.9%) 386/394 (98.0%) < 0.001
 Based on score ≥ 6 206/353 (58.4%) 384/394 (97.5%) < 0.001
 Typical RA erosion 60/318 (18.9%) 113/362 (31.2%) < 0.001
  1. “seronegative” early arthritis: patients negative for RF and ACPA; “seropositive” early arthritis: patients positive for RF and/or ACPA
  2. **Pearson’s chi-square test or Fisher’s exact test for categorical data and Wilcoxon test for continuous variables
  3. ♯ Nodules, dry eye, and dry mouth, salivary gland swelling, Raynaud syndrome, purpura, adenopathy, splenomegaly, pericarditis, pleural effusion, polyneuropathy, scleritis, keratitis, uveitis, carpal tunnel syndrome
  4. VAS visual analog scale, TJC tender joint count, SJC swollen joint count, anti-CCP anti-cyclic-citrullinated peptide, RF rheumatoid factor, ANA anti-nuclear antibodies, ESR erythrocyte sedimentation rate, CRP C-reactive protein, DAS28 Disease Activity Score in 28 joints, HAQ-DI Health Assessment Questionnaire Disability Index, mTSS modified total Sharp score, ACR/EULAR American College of Rheumatology/European League Against Rheumatism, RA rheumatoid arthritis
  5. P values were checkedEntries in italics were significant