Fig. 1

Patient flow chart: Randomisation was carried out in the initial randomised trial only (1:1 ratio to LBEC0101 or ETN-RP), and no further randomisation was carried out in the extension study. *The number of patients enrolled in the extension study is different from the number finishing the phase III study because only Korean patients were enrolled in the extension study. ETN-RP, etanercept reference product