Table 1 Characteristics of study participants
Metformin users N = 56 | Non-users N = 762 | p* | |
|---|---|---|---|
Baseline data | |||
Age, years | 62.3 (7.7) | 61.7 (8.5) | 0.64 |
Female, n (%) | 41 (73.2) | 492 (64.6) | 0.19 |
Body mass index, kg/m2 | 34.9 (3.8) | 33.9 (3.1) | 0.02 |
WOMAC pain score | 5.8 (4.4) | 4.3 (4.1) | 0.01 |
Kellgren-Lawrence grade, n (%) | 0.93 | ||
2 | 28 (50.0) | 386 (50.7) | |
3 | 21 (37.5) | 293 (38.4) | |
4 | 7 (12.5) | 83 (10.9) | |
Longitudinal data over 4–6 years | |||
Self-reported diabetes over 4 years, n (%) | 55 (98.2) | 68 (8.9) | < 0.001 |
Change in weight over 4 years, kg (n = 674) | − 1.4 (8.4) | − 0.6 (6.6) | 0.45 |
Annual % loss in cartilage volume over 4 years (n = 540) | |||
Medial compartment | 1.15 (1.29) | 1.53 (1.63) | 0.19 |
Lateral compartment | 1.31 (1.12) | 1.20 (1.40) | 0.65 |
Total knee replacement over 6 years, n (%) | 3 (5.4) | 88 (11.6) | 0.16 |