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Table 1 Characteristics of study participants

From: Association between metformin use and disease progression in obese people with knee osteoarthritis: data from the Osteoarthritis Initiative—a prospective cohort study

  Metformin users N = 56 Non-users N = 762 p*
Baseline data
 Age, years 62.3 (7.7) 61.7 (8.5) 0.64
 Female, n (%) 41 (73.2) 492 (64.6) 0.19
 Body mass index, kg/m2 34.9 (3.8) 33.9 (3.1) 0.02
 WOMAC pain score 5.8 (4.4) 4.3 (4.1) 0.01
Kellgren-Lawrence grade, n (%)    0.93
 2 28 (50.0) 386 (50.7)  
 3 21 (37.5) 293 (38.4)  
 4 7 (12.5) 83 (10.9)  
Longitudinal data over 4–6 years
 Self-reported diabetes over 4 years, n (%) 55 (98.2) 68 (8.9) < 0.001
 Change in weight over 4 years, kg (n = 674) − 1.4 (8.4) − 0.6 (6.6) 0.45
Annual % loss in cartilage volume over 4 years (n = 540)
 Medial compartment 1.15 (1.29) 1.53 (1.63) 0.19
 Lateral compartment 1.31 (1.12) 1.20 (1.40) 0.65
Total knee replacement over 6 years, n (%) 3 (5.4) 88 (11.6) 0.16
  1. Data presented as mean (standard deviation) or no (%)
  2. *For the difference between metformin users and non-users using independent samples t test or chi-square test