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Table 2 Association between metformin use and annual percentage loss in knee cartilage volume over 4 years

From: Association between metformin use and disease progression in obese people with knee osteoarthritis: data from the Osteoarthritis Initiative—a prospective cohort study

  Metformin users (mean, SE)1 Non-users (mean, SE)1 Difference (mean, 95% CI)1 P 1 Metformin users (mean, SE)2 Non-users (mean, SE)2 Difference (mean, 95% CI)2 P 2
Medial cartilage volume loss (%) 0.83 (0.34) 1.55 (0.07) − 0.72 (− 1.42, − 0.02) 0.04 0.71 (0.35) 1.57 (0.07) − 0.86 (− 1.58, − 0.15) 0.02
Lateral cartilage volume loss (%) 0.98 (0.29) 1.22 (0.06) − 0.24 (− 0.85, 0.36) 0.43 1.03 (0.28) 1.24 (0.06) − 0.20 (− 0.79, 0.38) 0.49
  1. SE standard error, CI confidence interval
  2. 1Adjusted for age, gender, body mass index, Kellgren-Lawrence grade, WOMAC pain score, and diabetes
  3. 2Adjusted for age, gender, body mass index, Kellgren-Lawrence grade, WOMAC pain score, diabetes, and weight change over 4 years