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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis

Fig. 1

The process of DNA methylation addition, maintenance and removal. The de novo establishment of DNA methylation is carried out by DNMT2, DNMT3A, DNMT3B and DNMT3L. Once established, DNA methylation requires maintenance to prevent loss of methylation either spontaneously through ‘passive’/spontaneous deamination or actively by the ten-eleven translocation (TET) enzymes. The TET protein family directly remove DNA methylation markers through successive oxidation steps followed by removal of thymine DNA glycosylase (TDG)

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Arthritis Research & Therapy

ISSN: 1478-6362

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