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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation

Fig. 1

STRING plot showing functional biomarker interrelationships. Depicted relationships represent biomarkers with significant associations with OA inflammation, radiographic OA, and OA symptoms analyzed using the STRING v10.5 database. The colors of the spheres correspond to the biological processes in which a particular biomarker is involved. Sphere color key: leukocyte migration (red), extracellular matrix organization (blue), and inflammatory response (green). Joining string color key (corresponding to origin of data used for STRING database): curated databases (blue), experimentally determined (pink), textmining (yellow), and co-expression (black). Abbreviations: CD, cluster of differentiation 14; CD163, cluster of differentiation 163; CCL2 (also referred to as MCP-1 or monocyte chemoattractant protein 1), C-C chemokine motif 2 vascular cell adhesion molecule 1; ELANE, neutrophil elastase; ICAM-1, intracellular adhesion molecule 1; MMP-3, matrix metalloproteinase-3; TIMP-1, tissue inhibitor of metallopeptidase inhibitor 1; VEGF, vascular endothelial growth factor

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