Table 1 Descriptive statistics for included biomarkers
| Â | Synovial fluid | Plasma | Â | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Biomarker | N | N outside LOD | Mean | IQR | N | N outside LOD | Mean | IQR | LLOD | Unit | Intra-assay CV (%) | Inter- assay CV (%) |
A2M | 48 | 0 | 0.17 | 0.11 | 25 | 0 | 0.42 | 0.11 | 0.051 | mg/mL | 7.26 | 13.75 |
AAT | 48 | 0 | 0.53 | 0.46 | 25 | 0 | 1.01 | 0.23 | 0.0065 | mg/mL | 4.93 | 9.33 |
B2M | 47 | 1 | 1.10 | 0.90 | 25 | 0 | 0.76 | 0.27 | 0.15 | μg/mL | 3.83 | 6.33 |
C3 | 47 | 1 | 0.13 | 0.14 | 25 | 0 | 0.57 | 0.18 | 0.00065 | mg/mL | 5.87 | 7.33 |
Factor7 | 44 | 4 | 66.29 | 74.91 | 25 | 0 | 484.88 | 143.00 | 5.60 | ng/mL | 3.13 | 8.00 |
Fibrinogen | 44 | 4 | 0.08 | 0.08 | 25 | 0 | 3.69 | 1.33 | 0.0056 | mg/mL | 5.47 | 10.67 |
FRTN | 48 | 0 | 271.66 | 229.63 | 24 | 1 | 41.14 | 41.00 | 6.23 | ng/mL | 5.67 | 11.33 |
sICAM-1 | 46 | 2 | 21.55 | 20.52 | 25 | 0 | 55.30 | 17.50 | 4.78 | ng/mL | 3.60 | 8.33 |
IL-1ra | 44 | 4 | 273.29 | 184.00 | 25 | 0 | 278.08 | 332.00 | 250.00 | pg/mL | 4.87 | 7.67 |
MCP-1 | 46 | 2 | 218.52 | 195.96 | 25 | 0 | 381.98 | 166.00 | 9.56 | pg/mL | 3.53 | 6.00 |
MMP-3 | 45 | 3 | 1.16 × 106 | 5.75 × 105 | 25 | 0 | 1.22 × 104 | 5.30 × 103 | 5.07 × 103 | pg/mL | 3.87 | 8.67 |
MMP-9 | 43 | 5 | 30.50 | 15.1 | 23 | 2 | 15.00 | 6.50 | 41.4 | ng/mL | 4.53 | 8.33 |
SCF | 45 | 3 | 198.56 | 77.00 | 25 | 0 | 94.75 | 38.50 | 195.6 | pg/mL | 3.47 | 6.67 |
TIMP-1 | 48 | 0 | 177.44 | 201.05 | 25 | 0 | 37.14 | 16.80 | 9.575 | ng/mL | 3.80 | 10.00 |
sVCAM-1 | 45 | 3 | 292.10 | 290.80 | 25 | 0 | 282.36 | 90.00 | 4.265 | ng/mL | 6.60 | 14.00 |
VDBP | 47 | 1 | 65.15 | 47.27 | 25 | 0 | 126.89 | 73.70 | 0.635 | μg/mL | 3.60 | 9.67 |
VEGF | 46 | 2 | 778.06 | 873.36 | 25 | 0 | 188.80 | 45.00 | 18.14 | pg/mL | 4.13 | 8.00 |