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Table 1 Descriptive statistics for included biomarkers

From: Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation

  Synovial fluid Plasma  
Biomarker N N outside LOD Mean IQR N N outside LOD Mean IQR LLOD Unit Intra-assay CV (%) Inter- assay CV (%)
A2M 48 0 0.17 0.11 25 0 0.42 0.11 0.051 mg/mL 7.26 13.75
AAT 48 0 0.53 0.46 25 0 1.01 0.23 0.0065 mg/mL 4.93 9.33
B2M 47 1 1.10 0.90 25 0 0.76 0.27 0.15 μg/mL 3.83 6.33
C3 47 1 0.13 0.14 25 0 0.57 0.18 0.00065 mg/mL 5.87 7.33
Factor7 44 4 66.29 74.91 25 0 484.88 143.00 5.60 ng/mL 3.13 8.00
Fibrinogen 44 4 0.08 0.08 25 0 3.69 1.33 0.0056 mg/mL 5.47 10.67
FRTN 48 0 271.66 229.63 24 1 41.14 41.00 6.23 ng/mL 5.67 11.33
sICAM-1 46 2 21.55 20.52 25 0 55.30 17.50 4.78 ng/mL 3.60 8.33
IL-1ra 44 4 273.29 184.00 25 0 278.08 332.00 250.00 pg/mL 4.87 7.67
MCP-1 46 2 218.52 195.96 25 0 381.98 166.00 9.56 pg/mL 3.53 6.00
MMP-3 45 3 1.16 × 106 5.75 × 105 25 0 1.22 × 104 5.30 × 103 5.07 × 103 pg/mL 3.87 8.67
MMP-9 43 5 30.50 15.1 23 2 15.00 6.50 41.4 ng/mL 4.53 8.33
SCF 45 3 198.56 77.00 25 0 94.75 38.50 195.6 pg/mL 3.47 6.67
TIMP-1 48 0 177.44 201.05 25 0 37.14 16.80 9.575 ng/mL 3.80 10.00
sVCAM-1 45 3 292.10 290.80 25 0 282.36 90.00 4.265 ng/mL 6.60 14.00
VDBP 47 1 65.15 47.27 25 0 126.89 73.70 0.635 μg/mL 3.60 9.67
VEGF 46 2 778.06 873.36 25 0 188.80 45.00 18.14 pg/mL 4.13 8.00
  1. Biomarkers listed yielded measurable values for ≥ 75% of samples
  2. Abbreviations: LOD limit of detection, IQR interquartile range, LLOD lower limit of detection, CV coefficient of variation, A2M alpha-2-macroglobulin, AAT alpha-1-antitrypsin, B2M beta-2-microglobulin, C3 complement C3, FRTN ferritin, sICAM-1 soluble intercellular adhesion molecule 1, IL-1ra interleukin-1 receptor antagonist, MCP-1 monocyte chemotactic protein 1, MMP-3 matrix metalloproteinase-3, MMP-9 matrix metalloproteinase-9, SCF stem cell factor, TIMP-1 tissue inhibitor of metalloproteinases 1, sVCAM-1 soluble vascular cell adhesion molecule-1, VDBP vitamin D-binding protein, VEGF vascular endothelial growth factor