Table 2 Synovial fluid biomarkers associated with features of osteoarthritis (inflammation, radiographic, and symptom severity)
| Â | Etarfolatide imaging | Radiographic severity | Symptom severity | ||
|---|---|---|---|---|---|
Synovial inflammation | KL | JSN | OST | PAS | |
Biomarker | Est. ×10−2 (95% CI) (pval) | Est. ×10−2 (95% CI) (pval) | Est. ×10−2 (95% CI) (pval) | Est. ×10−2 (95% CI) (pval) | Est. ×10−2 (95% CI) (pval) |
sVCAM-1 | 0.970 (0.330–1.610) (0.0029) | 0.160 (0.094–0.220) (< 0.0001) | 0.130 (0.052–0.002) (0.0009) | 0.430 (0.170–0.680) (0.0010) | 0.320 (0.120–0.510) (0.0015) |
MMP-3 | 52.712 (34.933–70.492) (< 0.0001) | 9.591 (5.289–13.982) (< 0.0001) | 6.477 (2.962–9.994) (0.0003) | 17.695 (− 4.989–40.378) (0.1263) | 15.220 (7.567–22.872) (< 0.0001) |
sICAM-1 | 16.120 (3.020–29.220) (0.0159) | 2.520 (1.400–3.630) (< 0.0001) | 2.270 (0.970–3.570) (0.0006) | 6.510 (3.250–9.780) (< 0.0001) | 5.980 (2.480–9.480) (0.0008) |
TIMP-1 | 1.470 (0.200–2.740) (0.0228) | 0.200 (0.110–0.300) (< 0.0001) | 0.140 (0.070–0.220) (0.0002) | 0.610 (0.430–0.800) (< 0.0001) | 0.790 (0.400–1.190) (< 0.0001) |
VEGF | 0.076 (− 0.310–0.460) (0.6985) | 0.100 (0.047–0.140) (0.0001) | 0.070 (0.013–0.130) (0.0160) | 0.250 (0.120–0.370) (0.0001) | 0.210 (0.130–0.300) (< 0.0001) |
MCP-1 | 0.470 (− 0.670–1.610) (0.4159) | 0.044(− 0.130–0.220) (0.6207) | 0.036 (− 0.120–0.190) (0.6529) | 0.310 (− 0.210–0.820) (0.2410) | 0.420 (0.073 – 0.760) (0.0175) |