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Table 2 Synovial fluid biomarkers associated with features of osteoarthritis (inflammation, radiographic, and symptom severity)

From: Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation

  Etarfolatide imaging Radiographic severity Symptom severity
Synovial inflammation KL JSN OST PAS
Biomarker Est. ×10−2 (95% CI)
(pval)
Est. ×10−2 (95% CI)
(pval)
Est. ×10−2 (95% CI)
(pval)
Est. ×10−2 (95% CI)
(pval)
Est. ×10−2 (95% CI)
(pval)
sVCAM-1 0.970 (0.330–1.610)
(0.0029)
0.160 (0.094–0.220)
(< 0.0001)
0.130 (0.052–0.002)
(0.0009)
0.430 (0.170–0.680)
(0.0010)
0.320 (0.120–0.510)
(0.0015)
MMP-3 52.712 (34.933–70.492)
(< 0.0001)
9.591 (5.289–13.982)
(< 0.0001)
6.477 (2.962–9.994)
(0.0003)
17.695 (− 4.989–40.378)
(0.1263)
15.220 (7.567–22.872)
(< 0.0001)
sICAM-1 16.120 (3.020–29.220)
(0.0159)
2.520 (1.400–3.630) (< 0.0001) 2.270 (0.970–3.570)
(0.0006)
6.510 (3.250–9.780)
(< 0.0001)
5.980 (2.480–9.480)
(0.0008)
TIMP-1 1.470 (0.200–2.740)
(0.0228)
0.200 (0.110–0.300)
(< 0.0001)
0.140 (0.070–0.220)
(0.0002)
0.610 (0.430–0.800)
(< 0.0001)
0.790 (0.400–1.190)
(< 0.0001)
VEGF 0.076 (− 0.310–0.460)
(0.6985)
0.100 (0.047–0.140)
(0.0001)
0.070 (0.013–0.130)
(0.0160)
0.250 (0.120–0.370)
(0.0001)
0.210 (0.130–0.300)
(< 0.0001)
MCP-1 0.470 (− 0.670–1.610)
(0.4159)
0.044(− 0.130–0.220)
(0.6207)
0.036 (− 0.120–0.190)
(0.6529)
0.310 (− 0.210–0.820)
(0.2410)
0.420 (0.073 – 0.760)
(0.0175)
  1. Estimates (Est × 10−2) of regression coefficient (Beta estimate), 95% confidence intervals, and raw p values are listed in the table; those meeting FDR < 0.05 are italicized
  2. Abbreviations: KL Kellgren-Lawrence; JSN joint space narrowing; OST osteophyte; PAS pain, aching and stiffness of knee; pval p value; CI confidence interval; sVCAM-1 soluble vascular cell adhesion molecule 1; MMP-3 matrix metalloproteinase-3; sICAM-1 soluble intracellular adhesion molecule 1; TIMP-1 tissue inhibitor of metallopeptidase inhibitor 1; VEGF vascular endothelial growth factor; MCP-1 monocyte chemoattractant protein 1