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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: Calorie restriction with regular chow, but not a high-fat diet, delays onset of spontaneous osteoarthritis in the Hartley guinea pig model

Fig. 4

a Dorsal and b sagittal reconstructions from a calorie-restricted animal with no OA lesions. MicroCT OA score of 0. c Dorsal reconstruction from an obese animal. There is sclerosis and small enthesiophytes on the medial femoral condyle (red arrows) and mild sclerosis of the central tibial plateau. d Sagittal reconstruction from same animal. Mild sclerosis of the cranial patella and caudal tibial condyle is present (blue arrows). MicroCT OA score of 6. e Dorsal reconstruction of an animal on the HFD. On the medial tibial condyle, there is a small osteophyte (green arrow). f HFD sagittal reconstruction. There is a small osteophyte on the proximal patella (green arrow), as well as mild sclerosis on the cranial patella (blue arrow). MicroCT OA score of 4

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