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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts

Fig. 2

Effect of activin A on cartilage invasion. a RASF were coimplanted together with healthy human cartilage into SCID mice. After 60 days, the invasion of RASF into cartilage was reduced by adenoviral activin A overexpression in comparison to control (n = 4 animals with n = 14 implants per group). By way of example, implants with GFP-transduced RASF (Basis) and for activin A overexpressing RASF are shown (c = cartilage). b OASF were activated with IL-1β to induce cartilage invasion, and activin A overexpression did not change IL-1β-induced OASF cartilage invasion (n = 5 implants without activin, n = 10 implants with activin). c Overexpression of activin A in RASF was confirmed by western blot. An MOI of 100 was used for implantation with mock-treated cells showing baseline activin A protein expression in RASF

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