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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts

Fig. 3

Synovial fibroblast stimulation with activin A suppresses follistatin. a Activin A suppressed follistatin protein release in RASF at all time points from 6 to 42 h (15 ng/ml activin A, n = 4). b Concentrations of 10–30 ng/ml activin A had the same suppressive effect on follistatin protein (shown for 15 h, n = 4). c Stimulation of RASF with activin A (15 ng/ml, n = 5) from 1.5 to 24 h resulted in a reduced expression of follistatin RNA. d When stimulating RASF for 3 h with 0 to 30 ng/ml activin A, a significant reduction of follistatin RNA expression was observed (15 h, n = 4). c, d 18S rRNA measurement served as the normalization control

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