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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts

Fig. 6

Effect of follistatin and activin AB on RASF and activin-induced Smad signaling. a Stimulation of RASF with follistatin showed a less than 2-fold reduction of activin A, IL-6, and proMMP1 (n = 3). b Stimulation with activin AB showed a significant follistatin reduction whereas IL-6 was less than 2-fold induced and no effect on proMMP-1 could be observed (n = 3). c In RASF (n = 3), activin A-mediated suppression of follistatin was confirmed in parallel to Smad2 phosphorylation. In these RASF, activin A strongly induced phosphorylation of Smad2. Results of two-tailed paired t test and mean ± SE are shown

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