Fig. 4

Nucleic acid receptors are differentially expressed in patients with SARDs. a CTD patients have increased expression of all of the NARs except TLR3. Comparisons were made using Dunn’s multiple comparison’s test. *p < 0.05, ***p < 0.001, ****p < 0.0001. RQ = relative quantification of gene expression. b Heatmap showing the relative expression of each of the 6 NARs. Each row represents a single patient and is K-means clustered into 6 groups. The rows are annotated by diagnostic group and by ISG score (ISG score-positive patients in green). c Correlation between the NAR expression and ISG score in the combined CTD cohort. The graphs show the Spearman r for each NAR