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Table 3 Association between autoantibodies and ISG score using logistic regression models

From: Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles

 

Odds ratio (95% CI)

Univariate model

Adjusted for age and gender

Adjusted model 1†

Adjusted model 2†

dsDNA

1.72 (0.862, 3.44)

1.45 (0.71, 2.97)

1.33 (0.576, 3.08)

1.47 (0.575, 3.74)

Ro (SS-A)

4.47 (2.20, 9.08)*

4.65 (2.24, 9.67)*

3.38 (1.37, 8.35)*

3.56 (1.32, 9.61)*

La (SS-B)

2.92 (1.18, 7.22)*

2.79 (1.11, 7.02)*

1.98 (0.602, 6.54)

2.50 (0.674, 9.26)

Smith

7.68 (2.68, 22.0)*

6.51 (2.23, 19.0)*

5.36 (1.61 17.8)*

8.35 (2.11, 32.7)*

RNP

4.76 (2.21, 10.2)*

4.07 (1.81, 9.14)*

4.11 (1.61, 10.5)*

4.08 (1.45, 11.5)*

Chromatin/nucleosome

6.29 (2.68, 14.8)*

5.57 (2.24, 13.9)*

5.13 (1.84, 14.3)*

8.09 (2.31, 28.4)*

Rheumatoid factor

4.88 (2.22, 10.7)*

5.53 (2.42, 12.6)*

7.77 (2.76, 21.9)*

7.26 (2.32, 22.7)*

Anti-CCP

2.31 (0.597, 8.91)

2.25 (0.577, 8.77)

1.46 (0.263, 8.07)

1.87 (0.272, 12.6)

SSc-specific ‡

0.835 (0.582, 1.20)

0.862 (0.592, 1.25)

1.00 (0.614, 1.64)

1.98 (0.237, 16.5)

  1. *p < 0.05
  2. ISG = interferon-stimulated gene
  3. †Model 1: adjusted for age, gender, ethnicity and clinical diagnosis
  4. Model 2: adjusted for above plus disease duration, anti-malarial, prednisolone and immunosuppressant use
  5. ‡Anti-Scl70, anti-centromere and anti-RNA-polymerase III
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Arthritis Research & Therapy

ISSN: 1478-6362

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