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Table 3 Association between autoantibodies and ISG score using logistic regression models

From: Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles

  Odds ratio (95% CI)
Univariate model Adjusted for age and gender Adjusted model 1† Adjusted model 2†
dsDNA 1.72 (0.862, 3.44) 1.45 (0.71, 2.97) 1.33 (0.576, 3.08) 1.47 (0.575, 3.74)
Ro (SS-A) 4.47 (2.20, 9.08)* 4.65 (2.24, 9.67)* 3.38 (1.37, 8.35)* 3.56 (1.32, 9.61)*
La (SS-B) 2.92 (1.18, 7.22)* 2.79 (1.11, 7.02)* 1.98 (0.602, 6.54) 2.50 (0.674, 9.26)
Smith 7.68 (2.68, 22.0)* 6.51 (2.23, 19.0)* 5.36 (1.61 17.8)* 8.35 (2.11, 32.7)*
RNP 4.76 (2.21, 10.2)* 4.07 (1.81, 9.14)* 4.11 (1.61, 10.5)* 4.08 (1.45, 11.5)*
Chromatin/nucleosome 6.29 (2.68, 14.8)* 5.57 (2.24, 13.9)* 5.13 (1.84, 14.3)* 8.09 (2.31, 28.4)*
Rheumatoid factor 4.88 (2.22, 10.7)* 5.53 (2.42, 12.6)* 7.77 (2.76, 21.9)* 7.26 (2.32, 22.7)*
Anti-CCP 2.31 (0.597, 8.91) 2.25 (0.577, 8.77) 1.46 (0.263, 8.07) 1.87 (0.272, 12.6)
SSc-specific ‡ 0.835 (0.582, 1.20) 0.862 (0.592, 1.25) 1.00 (0.614, 1.64) 1.98 (0.237, 16.5)
  1. *p < 0.05
  2. ISG = interferon-stimulated gene
  3. †Model 1: adjusted for age, gender, ethnicity and clinical diagnosis
  4. Model 2: adjusted for above plus disease duration, anti-malarial, prednisolone and immunosuppressant use
  5. ‡Anti-Scl70, anti-centromere and anti-RNA-polymerase III