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Table 2 Ultrasound inflammatory activity in the dominant hand versus the non-dominant hand, in the hand with clinically more swollen joint versus less swollen joints, and in the right hand versus left hand using different composite scores for the early and established RA cohorts combined

From: Assessing synovitis in the hands in patients with rheumatoid arthritis by ultrasound: an agreement study exploring the most inflammatory active side from two Norwegian trials

Baseline Change values from baseline to 3 months
  GS sum score (0–30) Doppler sum score (0–30) GLOESS (0–30) Δ GS sum score (0–30) Δ Doppler sum score (0–30) Δ GLOESS (0–30)
  Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI) Mean (95% CI)
*Dominant hand (n = 431)
 Dominant 7.75 (7.09 to 8.40) 4.81 (4.26 to 5.35) 8.07 (7.39 to 8.75) − 3.11(− 3.65 to − 2.57) − 2.57(− 3.10 to − 2.04) − 3.40(− 3.98 to − 2.82)
 Non-dominant 7.06 (6.41 to 7.72) 4.22 (3.68 to 4.78) 7.28 (6.60 to 7.96) − 3.12 (− 3.66 to − 2.58) − 2.35(− 2.88 to − 1.82) − 3.29(− 3.87 to − 2.71)
 Difference − 0.69 (− 1.61 to 0.24) − 0.58 (− 1.35 to 0.20) − 0.79 (− 1.76 to 0.18) − 0.005(− 0.76 to 0.75) 0.22(− 0.52 to 0.96) 0.11(− 0.70 to 0.92)
P value 0.15 0.14 0.11 0.99 0.57 0.79
*Clinical hand (n = 314)
 Worst clinical (more SJC) 8.51 (7.87 to 9.16) 5.37 (4.83 to 5.91) 8.83 (8.16 to 9.50) − 3.79 (− 4.32 to − 3.25) − 3.05(− 3.57 to − 2.52) − 4.06(− 4.63 to − 3.49)
 Least clinical (fewer SJC) 6.30 (5.65 to 6.94) 3.66 (3.13 to 4.20) 6.52 (5.85 to 7.19) − 2.45(− 2.98 to − 1.92) − 1.87(− 2.40 to − 1.35) − 2.64(− 3.21 to − 2.06)
 Difference − 2.21 (− 3.12 to − 1.30) − 1.70 (− 2.47 to − 0.94) − 2.31 (− 3.26 to − 1.36) 1.34 (0.60 to 2.08) 1.17 (0.44 to 1.91) 1.43 (0.63 to 2.22)
P value < .0001 < .0001 < .0001 0.0004 0.002 0.0005
*Hand side (n = 437)
Right side 7.78 (7.12 to 8.44) 4.82 (4.28 to 5.37) 8.12 (7.44 to 8.80) − 3.19(− 3.73 to − 2.65) − 2.64(− 3.17 to − 2.11) − 3.49(− 4.07 to − 2.91)
Left side 7.03 (6.37 to 7.68) 4.21 (3.6 to 4.76) 7.23 (6.55 to 7.91) − 3.05(− 3.59 to − 2.51) − 2.28(− 2.81 to − 1.75) − 3.21(− 3.78 to − 2.63)
 Difference − 0.75 (− 1.68 to 0.18) − 0.61 (− 1.38 to 0.16) − 0.89 (− 1.85 to 0.08) 0.14(− 0.61 to 0.89) 0.36(− 0.38 to 1.10) 0.29(− 0.52 to 1.09)
P value 0.11 0.12 0.07 0.71 0.34 0.49
  1. *Analyzed using a factor for the specific analyses (dominant, clinical and hand, respectively), and trial (ARCTIC and ULRABIT, respectively) as fixed effects, and the patient-ID was applied as a random effect
  2. SJC swollen joint count, Δ delta values from baseline to 3 months, GS grey scale, GLOESS the OMERACT-EULAR combined score