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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Antibodies against specific extractable nuclear antigens (ENAs) as diagnostic and prognostic tools and inducers of a profibrotic phenotype in cultured human skin fibroblasts: are they functional?

Fig. 1

Viability (top row) and apoptosis (bottom row) detected in control, unaffected LcSSc, affected LcSSc, and affected DcSSc fibroblasts at basal levels (untreated) and after stimulation with anti-Cenp-B (ratios 1:100 and 1:200)/anti-Topo-I (ratios 1:100 and 1:200) antibodies and with SSc sera (10% v/v in DMEM). Data were normalized per 104 cells. The statistics is reported with respect to the “Control.” “Control” for IgG stimulations is referred to human healthy control IgGs in a ratio 1:100 in culture medium (DMEM). “Control” for serum stimulation is referred to as human healthy control serum at 10% v/v in DMEM. (*p < 0.05, **p < 0.01). For SSc serum treatments, Cenp-B-/Topo-I treatment refers to SSc serum negative for all ENAs

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