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Table 1 Baseline characteristics of early RA patients from the tREACH

From: Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patients

 

Mean ± SD

Patients, N

294

Male, N (%)

87.0 (29.6%)

Age (years)

53.4 ± 14.2

DAS28 score

4.7 ± 1.2

DAS28 score 3 months*

3.0 ± 1.2

Erythrocyte folate (nmol/L)*

936.0 ± 356.2

BMI (kg/m2)*

26.3 ± 5.1

Smoking status*

 Current, N (%)

91.0 (31.0%)

 Never + former, N (%)

180.0 (61.2%)

ACPA status

 Positive, N (%)

193 (65.6%)

Treatment groups

 MTX, N (%)

54.0 (18.4%)

 MTX + prednisone p.o., N (%)

81.0 (27.6%)

 MTX + SSZ + HCQ + prednisone p.o., N (%)

83.0 (28.2%)

 MTX + SSZ + HCQ + corticosteroids i.m., N (%)

76.0 (25.9%)

  1. Abbreviations: SD standard deviation, SSZ sulfasalazine, HCQ hydroxychloroquine, BMI body mass index, p.o. per os, i.m. intramuscular
  2. *Data was missing for DAS28 score at T3 (n = 10), baseline erythrocyte folate (n = 75), BMI (n = 3), and smoking status (n = 23)