Table 2 Associations between baseline global DNA (hydroxy)methylation and ΔDAS28 before and after 3 months of therapy

1

Methylation

1.36 (0.67)

0.15

0.044

0.40 (0.55)

0.05

0.471

2

Methylation

1.41 (0.56)

0.15

0.013

0.44 (0.47)

0.06

0.385

DAS28

− 0.51 (0.06)

− 0.49

< 0.001

− 0.50 (0.06)

− 0.49

< 0.001

Erythrocyte folate (nmol/L)

− 1.00 × 10⁻³ (2.00 × 10⁻⁴)

− 0.17

0.006

− 4.00 × 10⁻⁴ (2.00 × 10⁻⁴)

− 0.12

0.063

BMI (kg/m²)

0.03 (0.02)

0.14

0.025

0.04 (0.02)

0.18

0.005

Age (years)

–

–

Sex

–

0.27 (0.16)

0.11

0.098

Smoking (current)

–

0.28 (0.16)

0.11

0.084

ACPA status (positive)

–

–

Observations

181

179

B (SE)

β

p

B (SE)

β

p

1

Hydroxymethylation

19.56 (18.38)

0.08

0.288

12.52 (19.26)

0.05

0.517

2

Hydroxymethylation

6.90 (15.89)

0.03

0.664

5.92 (16.75)

0.02

0.724

DAS28

− 0.54 (0.07)

− 0.52

< 0.001

− 0.52 (0.07)

− 0.51

< 0.001

Erythrocyte folate (nmol/L)

− 1.00 × 10⁻³ (2.00 × 10⁻⁴)

− 0.18

0.007

−5.00 × 10⁻⁴

(2.00 × 10⁻⁴)

− 0.14

0.035

BMI (kg/m²)

0.03 (0.02)

0.12

0.062

0.04 (0.02)

0.18

0.006

Age (years)

0.01 (0.01)

0.10

0.125

0.01 (0.01)

0.13

0.057

Sex

0.22 (0.17)

0.08

0.176

0.28 (0.16)

0.11

0.087

Smoking (current)

–

0.28 (0.16)

0.11

0.090

ACPA status (positive)

–

–

Observations

181

177