Table 4 Validation of associations between global DNA methylation with ΔDAS28 (T3-T0) in LINE-1 CpG2

Biomarkers

B (SE)

β

p

1

Methylation

0.09 (0.08)

0.13

0.242

2

Methylation

0.16 (0.07)

0.22

0.026

DAS28

− 0.49 (0.09)

− 0.53

< 0.001

Erythrocyte folate

− 1.00 × 10⁻³ (4.00 × 10⁻⁴)

− 0.12

0.197

BMI

0.03 (0.02)

0.16

0.100

Age

–

–

–

Sex

–

–

–

Smoking status

0.33 (0.23)

0.14

0.156

ACPA status

–

–

–

Observations

78