| |
Before MTX
|
|---|
| |
Biomarkers
|
B (SE)
|
β
|
p
|
|
1
|
Methylation
|
0.09 (0.08)
|
0.13
|
0.242
|
|
2
|
Methylation
|
0.16 (0.07)
|
0.22
|
0.026
|
| |
DAS28
|
− 0.49 (0.09)
|
− 0.53
|
< 0.001
|
| |
Erythrocyte folate
|
− 1.00 × 10−3 (4.00 × 10−4)
|
− 0.12
|
0.197
|
| |
BMI
|
0.03 (0.02)
|
0.16
|
0.100
|
| |
Age
|
–
|
–
|
–
|
|
Sex
|
–
|
–
|
–
|
|
Smoking status
|
0.33 (0.23)
|
0.14
|
0.156
|
| |
ACPA status
|
–
|
–
|
–
|
| |
Observations
| |
78
| |
- Association between % baseline (T0) global DNA methylation in LINE-1 element CpG2 with ΔDAS28 (T3-T0), tested in a crude univariate model (1) and adjusted for potential confounders (2). Potential confounders were baseline DAS28 score, baseline erythrocyte folate levels (nmol/L), BMI (kg/m2), age (years), sex, smoking status (current smoker versus former + never smoker), and ACPA positivity. Only biomarkers that changed the association with > 10% were considered confounders. B beta coefficient, SE standard error, β standardized beta coefficient. p < 0.05 was considered significant
