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Table 5 Linear regression models for the association between global DNA methylation before MTX and ΔDAS28 over 3 months stratified by treatment group

From: Higher baseline global leukocyte DNA methylation is associated with MTX non-response in early RA patients

Therapy

N

B (SE)

β

p

MTX

36

2.06 (1.12)

0.29

0.074

MTX + corticosteroids

48

1.51 (1.08)

0.18

0.172

MTX + SSZ + HCQ + corticosteroids

97

1.12 (0.81)

0.11

0.173

  1. Associations were adjusted for baseline DAS28, baseline erythrocyte folate, and BMI. MTX methotrexate, SSZ sulfasalazine, HCQ hydroxychloroquine, B beta coefficient, SE standard error, β standardized beta coefficient. p < 0.05 was considered significant
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Arthritis Research & Therapy

ISSN: 1478-6362

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