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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Prostaglandin receptor EP4 expression by Th17 cells is associated with high disease activity in ankylosing spondylitis

Fig. 5

Model of EP4 involvement in the generation of pathogenic Th17 cells in AS. PGE2 binds to the EP4 receptor and inhibits FoxO1 expression in Th17 cells. As a result, the IL-23 receptor (IL-23R) is upregulated. Activation of IL-23 receptor leads to Th17 cell accumulation and to an upregulation of EP4 in a positive feedback loop. The figure was adapted from Rundhaug et al. [45]

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Arthritis Research & Therapy

ISSN: 1478-6362

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