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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Rheumatoid arthritis synovial fibroblasts promote TREM-1 expression in monocytes via COX-2/PGE2 pathway

Fig. 1

TREM-1 expression is upregulated in CD14+ cells from synovial fluid in RA. Synovial cells and paired PBMC from synovial fluid (SF) and peripheral blood (PB) of 10 patients with RA were isolated by Ficoll-Hypaque density gradient. PBMC were obtained from the blood of 10 HC. Two-color flow cytometry was performed with fluorescein FITC-labeled anti-CD14 and APC-labeled anti-TREM-1. a Representative flow cytometric dot plots and histograms of TREM-1 expression on gated CD14+ cells isolated from SF and PB in RA and from PB in HC. Control staining was performed with IgG isotype (gray histogram). b Quantification of mean fluorescence intensity (MFI) of the TREM-1 expression of CD14+ cells in indicated groups. *P < 0.05, by ANOVA followed by Bonferroni’s post hoc test

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