Skip to main content
Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

Fig. 2

T cell responses towards SS-A/SS-B in pSS and HC. Antigen-specific T cell responses in pSS patients (grey circles) and HC (open circles) were examined in the absence of RO5459072 using IFN-γ/IL-17 dual ELISPOT (a, b) and proliferation assays (c). Surprisingly, there were no overall differences between pSS and HC with respect to frequencies of IFN-γ- and IL-17-secreting and proliferating T cells. Of note, whereas up to 250/106 PBMC-specific IFN-γ-secreting cells could be observed in some individuals, no relevant numbers of SS-A/SS-B-specific Th17 cells could be detected

Back to article page