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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

Fig. 3

Dose-dependent suppression of SS-A/SS-B-specific T cell responses by RO5459072. Of note, some pSS patients showed strong IFN-γ secretion (a) but no relevant proliferation towards SS-A/SS-B, whereas others were IFN-γ negative but showed specific proliferation (b). RO5459072 significantly diminished SS-A- and SS-B-specific T cell responses but also was capable of massively reducing SEB-induced proliferation of T cells (one-tailed t test * or § p < 0.05, ** or §§ or ++ p < 0.01, §§§ or +++ p < 0.001; ++++ p ≤ 0.0001), suggesting a mode of action independent of MHCII regulation

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