Fig. 4From: Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndromeUpper panel: SS-A and SS-B are potent monokine inducers. Both proteins induce IL-1β, IL-6, IL-10 and TNF-α in pSS patients with high T cell responses (responders (n = 7), see Fig. 4) but not in non-responders (n = 3) or HC (n = 4, except TNF-α for SS-A), (two-tailed t test *p < 0.05, **p < 0.01). Lower panel: RO5459072 suppresses monokines induced by SS-A and SS-B in pSS patients with strong cognate T cell responses (n = 6, see Fig. 4, one-tailed t test *p < 0.05, **p < 0.01)Back to article page