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Table 1 Baseline characteristics of primary Sjögren syndrome (pSS) patients enrolled

From: Differential effects of specific cathepsin S inhibition in biocompartments from patients with primary Sjögren syndrome

Patient

Sex

Age

Disease duration (y, mo)

Anti-SS-A

Anti-SS-B

Biopsy

Therapies

Manifestations

CRP/BSR

ESSDAI score

pSS 1

f

50

7mo

181

0.1

Neg

Artificial tears

Ocular sicca

Normal

0

pSS 2

f

43

11y 11mo

240

75

Pos

None

Ocular, oral and vaginal sicca, glandular swelling

Normal

2

pSS 3

f

76

36y 1mo

240

ND

ND

Artificial saliva

Ocular and oral sicca

Normal

0

pSS 4

f

48

11y 1mo

240

0.1

ND

CFZ-533 *, hydroxychloroquine

Ocular and oral sicca

ND

17

pSS 5

f

65

Unknown

131

3.2

ND

ND

ND

ND

ND

pSS 6

f

50

2y 2mo

240

5

Pos

None

Ocular sicca

Normal

0

pSS 7

m

40

16y 2mo

240

ND

Pos

Prednisolone p.o. and i.v., artificial tears

Ocular and oral sicca haematological manif., vasculitis, glandular swelling, pneumonitis

Elevated ESR & Elevated CRP

34

pSS 8

f

60

6mo

240

320

ND

None

Ocular and oral sicca

Elevated CRP

15

pSS 9

f

60

1mo

240

5

Pos

Artificial tears

Ocular and oral sicca

Normal

5

pSS 10

f

30

7mo

5

5

Pos

None

Ocular and oral sicca

Normal

0

pSS 11

m

60

1y 6mo

240

6

Pos

None

Ocular and oral sicca

Normal

1

pSS 12

f

53

3y 1mo

240

320

Pos

Methotrexate, hydroxychloroquine, artificial saliva

Ocular and oral sicca

Normal

6

pSS 13

f

51

9mo

20

ND

ND

Hydroxychloroquine, artificial tears, artificial saliva

Sicca

Normal

4

pSS 14

f

64

37y 6mo

240

298

Pos

Artificial saliva

Ocular and oral sicca

Normal

3

pSS 15

f

53

10mo

240

ND

Pos

Methotrexate, hydroxychloroquine, artificial saliva

Ocular, oral and vaginal sicca

Normal

8