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Table 2 Analysis of annual BMD change in the lumbar spine

From: Distinct biomarkers for different bones in osteoporosis with rheumatoid arthritis

Parameter Univariate analysis Multivariable regression analysis (full model) Multivariable regression analysis (reduced model)
t 95%CI p t 95%CI t 95%CI
Female over 60 years old −1.96 − 0.03~0.27 0.051 1.80 − 0.05~0.06   
BMI − 0.29 − 0.14~0.10 0.77 0.10 − 0.11~0.12   
HbA1c (NGSP) 0.66 − 0.47~0.94 0.51 0.56 − 0.55~0.98   
DAS28-ESR 0.06 − 0.32~0.34 0.95 1.98* 0.001~0.73 − 0.01 − 0.38~0.37
HAQ 0.48 − 0.38~0.63 0.63 0.20 − 0.60~0.73   
TSS − 0.26 − 0.66~0.51 0.31 2.15* 0.001~0.008 1.62 − 0.001~ − 0.01
MTX dose − 1.10 − 0.14~0.04 0.95 − 0.37 − 0.12~0.08   
Steroid dose 2.08 0.01~0.28 0.04* 1.43 − 0.04~0.27 1.54 −0.03~0.26
bDMARD 0.83 − 0.73~0.57 0.41 − 0.60 − 0.60~0.32   
Bisphosphonate 2.41 0.15~1.44 0.02* 007 − 0.02~0.82 2.45* 0.10~0.95
Vitamin D 2.34 0.11~1.29 0.02* 0.87 − 0.27~0.58   
RF − 0.60 − 0.004~0.002 0.55 0.48 − 0.003~0.005   
ACPA − 0.84 − 0.005~0.002 0.40 − 1.52 − 0.007~0.001 −1.53 − 0.01~0.001
CRP 0.23 − 0.25~0.31 0.82 − 2.48* − 0.95~ − 0.11 0.01 −0.31~0.32
TRACP-5b − 0.86 − 0.003~0.001 0.39 − 1.66 − 0.01~0.001   
Homocysteine − 1.97 − 0.21~ − 0.0001 0.049* − 2.55* − 0.30~ − 0.04 − 2.38* −0.26~ − 0.02
Uc-OC − 0.96 − 0.13~0.05 0.34 0.45 − 0.09~0.03   
BAP − 0.24 − 0.06~0.05 0.81 0.95 − 0.04~0.12   
Urine pentosidine 1.59 − 0.003~0.03 0.11 1.63 − 0.002~0.03 1.45 −0.004~0.03
  1. BMD bone mineral density, BMI body mass index, DAS28-ESR disease activity score in 28 joints-erythrocyte sedimentation rate, HAQ health assessment questionnaire, TSS total Sharp/van der Heijde score, MTX methotrexate, bDMARDs biological disease-modifying anti-rheumatic drugs, RF rheumatoid factor, ACPA anti-cyclic citrullinated peptide antibody, CRP C-reactive protein, TRACP-5b tartrate-resistant acid phosphatase 5b, Uc-OC undercarboxylated osteocalcin, BAP bone-specific alkaline phosphatase
  2. *p ≥ 0.05