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Table 3 Analysis of annual BMD change in the proximal femur

From: Distinct biomarkers for different bones in osteoporosis with rheumatoid arthritis

Parameter Univariate analysis Multivariable regression analysis (full model) Multivariable regression analysis (reduced model)
t 95%CI p t 95%CI t 95%CI
Female over 60 years old −0.30 − 0.52~0.38 0.76 − 0.12 − 0.27~0.24   
BMI −0.85 − 0.10~0.04 0.40 0.26 − 0.07~0.09   
HbA1c (NGSP) −0.90 − 0.67~0.25 0.36 −1.04 − 0.76~0.24 0.12 − 0.80~0.09
DAS28-ESR −1.98 − 0.40~ − 0.001 0.049* 0.06 − 0.25~0.26   
HAQ 0.48 − 0.38~0.63 0.63 − 0.81 − 0.56~0.24 −1.65 − 0.56~0.05
TSS −0.26 − 0.66~0.51 0.31 − 0.40 − 0.003~0.002   
MTX dose −0.12 − 0.06~0.05 0.90 − 0.52 − 0.08~0.05   
Steroid dose 0.52 − 0.06~0.11 0.60 0.05 − 0.09~0.10   
bDMARD 1.89 − 0.02~0.92 0.06 0.35 − 0.15~0.42   
Bisphosphonate 3.08 0.26~1.20 0.002* 3.53* 0.20~0.72 3.19* 0.15~0.62
Vitamin D 2.58 0.13~1.04 0.01* 2.72* 0.10~0.59 2.99* 0.12~0.58
RF −0.60 − 0.004~0.002 0.55 1.07 − 0.001~0004   
ACPA −2.09 − 0.004~ − 0.0001 0.04* − 2.34* − 0.01~ − 0.001 − 2.42* − 0.004~ − 0.0004
CRP −4.03 − 0.49~ − 0.17 < 0.001* − 0.71 − 0.36~0.17   
TRACP-5b −1.89 − 0.003~0.001 0.06 −1.00 − 0.003~0.001   
Homocysteine −1.81 − 0.12~ − 0.005 0.07 − 018 − 0.09~0.07   
Uc-OC 0.66 − 0.06~0.04 0.65 0.68 − 0.04~0.09   
BAP −1.20 − 0.05~0.01 0.23 0.68 − 0.03~0.06   
Urine pentosidine −0.71 − 0.01~0.006 0.47 − 0.08 − 0.01~0.01   
  1. BMD bone mineral density, BMI body mass index, DAS28-ESR disease activity score in 28 joints-erythrocyte sedimentation rate, HAQ health assessment questionnaire, TSS total Sharp/van der Heijde score, MTX methotrexate, bDMARDs biological disease-modifiying anti-rheumatic drugs, RF rheumatoid factor, ACPA anti-cyclic citrullinated peptide antibody, CRP C-reactive protein, TRACP-5b tartrate-resistant acid phosphatase 5b, Uc-OC undercarboxylated osteocalcin, BAP bone-specific alkaline phosphatase
  2. *p ≥ 0.05