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Table 4 Analysis of annual BMD change in the distal forearm

From: Distinct biomarkers for different bones in osteoporosis with rheumatoid arthritis

Parameter

Univariate analysis

Multivariable regression analysis (full model)

Multivariable regression analysis (reduced model)

t

95%CI

p

t

95%CI

t

95%CI

Female over 60 years old

0.91

− 0.28~0.75

0.37

1.17

− 0.11~0.45

  

BMI

− 0.46

− 0.10~0.06

0.64

0.87

− 0.05~0.13

  

HbA1c (NGSP)

− 0.48

− 0.65~0.40

0.63

− 0.43

− 0.68~0.44

  

DAS28-ESR

− 1.47

− 0.40~0.06

0.14

0.98

− 0.28~0.29

  

HAQ

0.49

− 0.26~0.43

0.63

− 1.05

− 0.69~0.21

  

TSS

1.39

− 0.001~0.004

0.31

1.43

− 0.001~0.004

1.64

− 0.0003~0.004

MTX dose

− 2.23

− 0.13~ − 0.01

0.03*

− 0.64

− 0.10~0.05

  

Steroid dose

1.56

− 0.02~0.17

0.12

0.21

− 0.10~0.12

  

bDMARD

1.34

− 0.17~0.90

0.18

0.05

− 0.31~0.32

  

Bisphosphonate

2.45

0.13~1.20

0.02*

2.04*

0.01~0.59

2.06*

0.01~0.55

Vitamin D

2.26

0.07~1.10

0.03*

2.63*

0.10~0.64

2.07*

0.01~0.52

RF

0.28

− 0.002~0.002

0.79

− 0.39

− 0.001~0.004

  

ACPA

0.93

− 0.001~0.003

0.35

1.17

− 0.001~0.004

  

CRP

− 0.51

− 0.24~0.14

0.61

− 0.83

− 0.42~0.17

  

TRACP-5b

− 2.54

− 0.004~ − 0.005

0.01*

− 3.18*

− 0.01~ − 0.001

−3.27*

− 0.005~ − 0.001

Homocysteine

0.71

− 0.05~0.10

0.48

− 0.17

− 0.10~0.08

  

Uc-OC

− 0.83

− 0.09~0.04

0.40

0.05

− 0.07~0.08

  

BAP

− 0.41

− 0.05~0.03

0.68

1.51

− 0.01~0.10

1.80

− 0.004~0.10

Urine pentosidine

0.47

− 0.01~0.01

0.64

0.96

− 0.005~0.02

  
  1. BMD bone mineral density, BMI body mass index, DAS28-ESR disease activity score in 28 joints-erythrocyte sedimentation rate, HAQ health assessment questionnaire, TSS total Sharp/van der Heijde score, MTX methotrexate, bDMARDs biological disease-modifying anti-rheumatic drugs, RF rheumatoid factor, ACPA anti-cyclic citrullinated peptide antibody, CRP C-reactive protein, TRACP-5b tartrate-resistant acid phosphatase 5b, Uc-OC undercarboxylated osteocalcin, BAP bone-specific alkaline phosphatase
  2. *p ≥ 0.05