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Table 4 Analysis of annual BMD change in the distal forearm

From: Distinct biomarkers for different bones in osteoporosis with rheumatoid arthritis

Parameter Univariate analysis Multivariable regression analysis (full model) Multivariable regression analysis (reduced model)
t 95%CI p t 95%CI t 95%CI
Female over 60 years old 0.91 − 0.28~0.75 0.37 1.17 − 0.11~0.45   
BMI − 0.46 − 0.10~0.06 0.64 0.87 − 0.05~0.13   
HbA1c (NGSP) − 0.48 − 0.65~0.40 0.63 − 0.43 − 0.68~0.44   
DAS28-ESR − 1.47 − 0.40~0.06 0.14 0.98 − 0.28~0.29   
HAQ 0.49 − 0.26~0.43 0.63 − 1.05 − 0.69~0.21   
TSS 1.39 − 0.001~0.004 0.31 1.43 − 0.001~0.004 1.64 − 0.0003~0.004
MTX dose − 2.23 − 0.13~ − 0.01 0.03* − 0.64 − 0.10~0.05   
Steroid dose 1.56 − 0.02~0.17 0.12 0.21 − 0.10~0.12   
bDMARD 1.34 − 0.17~0.90 0.18 0.05 − 0.31~0.32   
Bisphosphonate 2.45 0.13~1.20 0.02* 2.04* 0.01~0.59 2.06* 0.01~0.55
Vitamin D 2.26 0.07~1.10 0.03* 2.63* 0.10~0.64 2.07* 0.01~0.52
RF 0.28 − 0.002~0.002 0.79 − 0.39 − 0.001~0.004   
ACPA 0.93 − 0.001~0.003 0.35 1.17 − 0.001~0.004   
CRP − 0.51 − 0.24~0.14 0.61 − 0.83 − 0.42~0.17   
TRACP-5b − 2.54 − 0.004~ − 0.005 0.01* − 3.18* − 0.01~ − 0.001 −3.27* − 0.005~ − 0.001
Homocysteine 0.71 − 0.05~0.10 0.48 − 0.17 − 0.10~0.08   
Uc-OC − 0.83 − 0.09~0.04 0.40 0.05 − 0.07~0.08   
BAP − 0.41 − 0.05~0.03 0.68 1.51 − 0.01~0.10 1.80 − 0.004~0.10
Urine pentosidine 0.47 − 0.01~0.01 0.64 0.96 − 0.005~0.02   
  1. BMD bone mineral density, BMI body mass index, DAS28-ESR disease activity score in 28 joints-erythrocyte sedimentation rate, HAQ health assessment questionnaire, TSS total Sharp/van der Heijde score, MTX methotrexate, bDMARDs biological disease-modifying anti-rheumatic drugs, RF rheumatoid factor, ACPA anti-cyclic citrullinated peptide antibody, CRP C-reactive protein, TRACP-5b tartrate-resistant acid phosphatase 5b, Uc-OC undercarboxylated osteocalcin, BAP bone-specific alkaline phosphatase
  2. *p ≥ 0.05