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Table 1 Demographic and baseline characteristics of patients

From: Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study

  BCL high dose, N = 49 BCL low dose, N = 47 Placebo, N = 45
Age (years)
 Mean (SD) 60.9 (9.78) 61.4 (7.49) 63.3 (7.69)
Sex, n (%)
 Female 39 (79.6) 40 (85.1) 34 (75.6)
BMI (kg/m2)
 Mean (SD) 29.4 (4.87) 30.4 (5.23) 29.4 (5.2)
Time from diagnosis of knee OA (years)
 Mean (SD) 7.41 (7.294) 6.6 (4.671) 7.6 (9.3)
KL grade, n (%)
 Grade I 0 (0.0%) 0 (0.0%) 0 (0.0%)
 Grade II 31 (63.3%) 27 (57.4%) 29 (64.4%)
 Grade III 18 (36.7%) 19 (40.4%) 16 (35.6%)
 Grade IV 0 (0.0%) 1 (2.0%) 0 (0.0%)
Target knee (the most symptomatic), n (%)
 Right 27 (55.1%) 22 (46.8%) 25 (55.6%)
Target knee pain (VAS, mm)
 Mean (SD) 62.9 (13.8) 63.3 (15.8) 59.9 (12.3)
PGADA (VAS, mm)
 Mean (SD) 67.2 (17.5) 69.6 (17.8) 63.9 (17.3)
Coll2-1 (nM)
 Mean (SD) 393.39 (165.2) 373.8 (133.5) 384.7 (122.0)
Ultra-sensitive CRP (mg/l)
 Mean (SD) 2.5 (2.5) 3.4 (2.9) 3.2 (2.8)
Rescue treatment (NSAIDs) in the last month, n (%)
 No 15 (30.6%) 12 (25.5%) 13 (28.9%)
 Less than 7 days 5 (10.2%) 2 (4.3%) 2 (4.4%)
 7 to 14 days 15 (30.6%) 19 (40.4%) 16 (35.6%)
 15 to 21 days 4 (8.2%) 9 (19.1%) 5 (11.1%)
 More than 21 days 7 (14.3%) 2 (4.3%) 6 (13.3%)
 Every day 2 (4.1%) 3 (6.4%) 3 (6.7%)
 NI 1 (2.0%) 0 (0.0%) 0 (0.0%)
Rescue treatment (paracetamol) in the last month, n (%)
 No 6 (12.2%) 3 (6.4%) 2 (4.4%)
 Less than 7 days 1 (2.0%) 3 (6.4%) 2 (4.4%)
 7 to 14 days 27 (55.1%) 18 (38.3%) 21 (46.7%)
 15 to 21 days 3 (6.1%) 11 (23.4%) 8 (17.8%)
 More than 21 days 4 (8.2%) 6 (12.8%) 7 (15.6%)
 Every day 8 (16.3%) 6 (12.8%) 5 (11.1%)
 NI 6 (12.2%) 3 (6.4%) 2 (4.4%)
KOOS—global score
 Mean (SD) 199.2 (68.1) 201.5 (73.5) 197.7 (60.0)
KOOS—pain
 Mean (SD) 45.3 (16.4) 45.8 (15.6) 44.2 (13.9)
KOOS—ADL
 Mean (SD) 49.8 (17.9) 48.9 (17.3) 48.9 (16.6)
KOOS—QoL
 Mean (SD) 32.0 (18.7) 31.5 (19.2) 33.3 (18.1)
KOOS—symptoms
 Mean (SD) 52.15 (15.9) 52.8 (15.6) 54.1 (13.5)
KOOS—Sport and rec.
 Mean (SD) 19.5 (17.1) 19.8 (19.8) 17.2 (14.5)
  1. ADL activity of daily life, BMI Body Mass Index, NSAID non-steroidal anti-inflammatory drug, KL Kellgren-Lawrence, NI no information, OA osteoarthritis, PAGDA Patient Global Assessment of Disease Activity, QoL Quality of life, SD Standard Deviation, VAS Visual Analog Scale