Skip to main content

Table 1 Demographic and baseline characteristics of patients

From: Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study

 

BCL high dose, N = 49

BCL low dose, N = 47

Placebo, N = 45

Age (years)

 Mean (SD)

60.9 (9.78)

61.4 (7.49)

63.3 (7.69)

Sex, n (%)

 Female

39 (79.6)

40 (85.1)

34 (75.6)

BMI (kg/m2)

 Mean (SD)

29.4 (4.87)

30.4 (5.23)

29.4 (5.2)

Time from diagnosis of knee OA (years)

 Mean (SD)

7.41 (7.294)

6.6 (4.671)

7.6 (9.3)

KL grade, n (%)

 Grade I

0 (0.0%)

0 (0.0%)

0 (0.0%)

 Grade II

31 (63.3%)

27 (57.4%)

29 (64.4%)

 Grade III

18 (36.7%)

19 (40.4%)

16 (35.6%)

 Grade IV

0 (0.0%)

1 (2.0%)

0 (0.0%)

Target knee (the most symptomatic), n (%)

 Right

27 (55.1%)

22 (46.8%)

25 (55.6%)

Target knee pain (VAS, mm)

 Mean (SD)

62.9 (13.8)

63.3 (15.8)

59.9 (12.3)

PGADA (VAS, mm)

 Mean (SD)

67.2 (17.5)

69.6 (17.8)

63.9 (17.3)

Coll2-1 (nM)

 Mean (SD)

393.39 (165.2)

373.8 (133.5)

384.7 (122.0)

Ultra-sensitive CRP (mg/l)

 Mean (SD)

2.5 (2.5)

3.4 (2.9)

3.2 (2.8)

Rescue treatment (NSAIDs) in the last month, n (%)

 No

15 (30.6%)

12 (25.5%)

13 (28.9%)

 Less than 7 days

5 (10.2%)

2 (4.3%)

2 (4.4%)

 7 to 14 days

15 (30.6%)

19 (40.4%)

16 (35.6%)

 15 to 21 days

4 (8.2%)

9 (19.1%)

5 (11.1%)

 More than 21 days

7 (14.3%)

2 (4.3%)

6 (13.3%)

 Every day

2 (4.1%)

3 (6.4%)

3 (6.7%)

 NI

1 (2.0%)

0 (0.0%)

0 (0.0%)

Rescue treatment (paracetamol) in the last month, n (%)

 No

6 (12.2%)

3 (6.4%)

2 (4.4%)

 Less than 7 days

1 (2.0%)

3 (6.4%)

2 (4.4%)

 7 to 14 days

27 (55.1%)

18 (38.3%)

21 (46.7%)

 15 to 21 days

3 (6.1%)

11 (23.4%)

8 (17.8%)

 More than 21 days

4 (8.2%)

6 (12.8%)

7 (15.6%)

 Every day

8 (16.3%)

6 (12.8%)

5 (11.1%)

 NI

6 (12.2%)

3 (6.4%)

2 (4.4%)

KOOS—global score

 Mean (SD)

199.2 (68.1)

201.5 (73.5)

197.7 (60.0)

KOOS—pain

 Mean (SD)

45.3 (16.4)

45.8 (15.6)

44.2 (13.9)

KOOS—ADL

 Mean (SD)

49.8 (17.9)

48.9 (17.3)

48.9 (16.6)

KOOS—QoL

 Mean (SD)

32.0 (18.7)

31.5 (19.2)

33.3 (18.1)

KOOS—symptoms

 Mean (SD)

52.15 (15.9)

52.8 (15.6)

54.1 (13.5)

KOOS—Sport and rec.

 Mean (SD)

19.5 (17.1)

19.8 (19.8)

17.2 (14.5)

  1. ADL activity of daily life, BMI Body Mass Index, NSAID non-steroidal anti-inflammatory drug, KL Kellgren-Lawrence, NI no information, OA osteoarthritis, PAGDA Patient Global Assessment of Disease Activity, QoL Quality of life, SD Standard Deviation, VAS Visual Analog Scale