| BCL high dose, N = 49 | BCL low dose, N = 47 | Placebo, N = 45 |
---|---|---|---|
Age (years) | |||
 Mean (SD) | 60.9 (9.78) | 61.4 (7.49) | 63.3 (7.69) |
Sex, n (%) | |||
 Female | 39 (79.6) | 40 (85.1) | 34 (75.6) |
BMI (kg/m2) | |||
 Mean (SD) | 29.4 (4.87) | 30.4 (5.23) | 29.4 (5.2) |
Time from diagnosis of knee OA (years) | |||
 Mean (SD) | 7.41 (7.294) | 6.6 (4.671) | 7.6 (9.3) |
KL grade, n (%) | |||
 Grade I | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
 Grade II | 31 (63.3%) | 27 (57.4%) | 29 (64.4%) |
 Grade III | 18 (36.7%) | 19 (40.4%) | 16 (35.6%) |
 Grade IV | 0 (0.0%) | 1 (2.0%) | 0 (0.0%) |
Target knee (the most symptomatic), n (%) | |||
 Right | 27 (55.1%) | 22 (46.8%) | 25 (55.6%) |
Target knee pain (VAS, mm) | |||
 Mean (SD) | 62.9 (13.8) | 63.3 (15.8) | 59.9 (12.3) |
PGADA (VAS, mm) | |||
 Mean (SD) | 67.2 (17.5) | 69.6 (17.8) | 63.9 (17.3) |
Coll2-1 (nM) | |||
 Mean (SD) | 393.39 (165.2) | 373.8 (133.5) | 384.7 (122.0) |
Ultra-sensitive CRP (mg/l) | |||
 Mean (SD) | 2.5 (2.5) | 3.4 (2.9) | 3.2 (2.8) |
Rescue treatment (NSAIDs) in the last month, n (%) | |||
 No | 15 (30.6%) | 12 (25.5%) | 13 (28.9%) |
 Less than 7 days | 5 (10.2%) | 2 (4.3%) | 2 (4.4%) |
 7 to 14 days | 15 (30.6%) | 19 (40.4%) | 16 (35.6%) |
 15 to 21 days | 4 (8.2%) | 9 (19.1%) | 5 (11.1%) |
 More than 21 days | 7 (14.3%) | 2 (4.3%) | 6 (13.3%) |
 Every day | 2 (4.1%) | 3 (6.4%) | 3 (6.7%) |
 NI | 1 (2.0%) | 0 (0.0%) | 0 (0.0%) |
Rescue treatment (paracetamol) in the last month, n (%) | |||
 No | 6 (12.2%) | 3 (6.4%) | 2 (4.4%) |
 Less than 7 days | 1 (2.0%) | 3 (6.4%) | 2 (4.4%) |
 7 to 14 days | 27 (55.1%) | 18 (38.3%) | 21 (46.7%) |
 15 to 21 days | 3 (6.1%) | 11 (23.4%) | 8 (17.8%) |
 More than 21 days | 4 (8.2%) | 6 (12.8%) | 7 (15.6%) |
 Every day | 8 (16.3%) | 6 (12.8%) | 5 (11.1%) |
 NI | 6 (12.2%) | 3 (6.4%) | 2 (4.4%) |
KOOS—global score | |||
 Mean (SD) | 199.2 (68.1) | 201.5 (73.5) | 197.7 (60.0) |
KOOS—pain | |||
 Mean (SD) | 45.3 (16.4) | 45.8 (15.6) | 44.2 (13.9) |
KOOS—ADL | |||
 Mean (SD) | 49.8 (17.9) | 48.9 (17.3) | 48.9 (16.6) |
KOOS—QoL | |||
 Mean (SD) | 32.0 (18.7) | 31.5 (19.2) | 33.3 (18.1) |
KOOS—symptoms | |||
 Mean (SD) | 52.15 (15.9) | 52.8 (15.6) | 54.1 (13.5) |
KOOS—Sport and rec. | |||
 Mean (SD) | 19.5 (17.1) | 19.8 (19.8) | 17.2 (14.5) |