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Table 4 Highly upregulated proteins in tear fluid of pSS patients

From: Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers

Number Gene Related protein* Classification and function**
Non-SS vs. pSS
 1 LMO7 LIM domain only protein 7 Ubiquitination, cell signalling, cell adhesion
 2 HUWE1 E3 ubiquitin-protein ligase HUWE1 Mediates ubiquitination, neutrophil degranulation, cell differentiation
 3 TPD52 Tumour protein D52 B cell differentiation, cell proliferation, Ca2+-signalling
Controls vs. pSS
 1 LMO7 LIM domain only protein 7 Ubiquitination, cell signalling, cell adhesion
 2 HUWE1 E3 ubiquitin-protein ligase HUWE1 Mediates ubiquitination, neutrophil degranulation, cell differentiation
 3 TPD52 Tumour protein D52 B cell differentiation, cell proliferation, Ca2+-signalling
  1. *The three most upregulated immunological proteins in whole saliva of pSS patients deviating in replicates, i.e. number of individuals (frequency), and spectral counts, as identified by proteomics analysis and Scaffold (v 4.4.6, http://www.proteomesoftware.com/products/scaffold/)
  2. **The classification and functions of the proteins presented were identified using publicly available databases, such as UniProt (http://www.uniprot.org)