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Table 6 Highly upregulated proteins in EVs isolated from stimulated whole saliva of pSS patients

From: Proteomic and histopathological characterisation of sicca subjects and primary Sjögren’s syndrome patients reveals promising tear, saliva and extracellular vesicle disease biomarkers

Number Gene Related protein* Classification and function**
Non-SS vs. pSS
 1 CD44 CD44 antigen FOXP3 expression and regulatory T-cell suppression, promotes tumour growth
 2 MVP Major vault protein IFNγ-mediated signalling, MAP kinase activity, neutrophil degranulation
 3 NGAL Neutrophil gelatinase-associated lipocalin Innate immunity, tumour-associated antigen, cell adhesion
Controls vs. pSS
 1 FCN1 Ficolin-1 Pattern-recognition receptor in innate immunity, complement activation
 2 CD44 CD44 antigen FOXP3 expression and regulatory T-cell suppression, promotes tumour growth
 3 ANXA4 Annexin A4 NF-kappaB binding, apoptosis, IL-8 secretion
  1. *The three most upregulated immunological proteins in whole saliva of pSS patients deviating in replicates i.e. number of individuals (frequency), and spectral counts, as identified by proteomics analysis and Scaffold (v 4.4.6, http://www.proteomesoftware.com/products/scaffold/)
  2. **The classification and functions of the proteins presented were identified using publicly available databases, such as UniProt (http://www.uniprot.org)
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