Fig. 1

a Clinical scoring (weight, inflammation, grimace, behaviour, mobility, inflammation severity and duration); b scoring of joint inflammation; c quantification of cortical erosion (arbitrary units) in the bones of the ankle, metatarsals and phalanges; d representative images of 3D reconstructions of hind paws using micro-CT; e histological scoring of synovitis (arbitrary units); f histological scoring (arbitrary units) of TRAP +ve osteoclast numbers at the ulna/humerus joint interface; g representative images of synovitis at the ulna/humerus joint interface; h representative images of TRAP +ve osteoclast numbers at the ulna/humerus joint interface; and i serum IL-6 levels determined by ELISA in WT and TNF-tg animals receiving either vehicle or corticosterone (100 μg/mL) in drinking water over 3 weeks. Values are expressed as mean ± standard error of six animals per group. Statistical significance was determined using two-way ANOVA with a Tukey post hoc analysis. Black arrows indicate sites of full-thickness cortical erosions. *P < 0.05, **P < 0.005, ***P < 0.001