Fig. 4

Tofacitinib inhibits the phosphorylation of STAT1 and STAT5 in MDSCs from the inflamed lung. a Representative flow cytometry plots of phosphorylated STATs in MDSCs from the lungs of control mice and tofacitinib-treated mice. b Comparison of mean fluorescence intensity (MFI) of phosphorylated STATs in lung-infiltrating MDSCs from control mice (n = 5) versus tofacitinib-treated mice (n = 5). Data are shown as the mean ± SEM. *P < 0.05, **P < 0.01, Student’s t tests