Skip to main content

Table 1 Characteristics of the selected studies

From: Prognostic factors for progression of osteoarthritis of the hip: a systematic review

Study

Design

Participants in the cohort (n)

Assessment of progression

Follow-up period

Agricola et al. [11]

Prospective cohort (CHECK)

1002 (analyzed 723 patients)

THR

5 years

Agricola et al. [12]

Prospective cohort (CHECK)

1002 (analyzed 550 women)

THR due to OA

5 years

Agricola et al. [12]

Nested case-control (Chingford cohort)

1003 (analyzed 114)

THR due to OA

19 years

Auquier et al. [13]

Retrospective cohort

131

Increase in stage of pain and function, stages minimal, moderate, moderate-severe, severe

6–23 years

Barr et al. [14]

Case-control

195 (analyzed 102 patients)

THR (compared to non-progression hips: increase of ≤ 1 K-L grade)

5 years

Bastick et al. [15]

Prospective cohort (CHECK)

545 (analyzed 363 patients)

NRS score for pain, group moderate progression compared to mild pain. Groups based on LCGA

5 years

Bastick et al. [16]

Prospective cohort (CHECK)

588 (analyzed 538)

THR

5 years

Bergink et al. [17]

Prospective cohort (Rotterdam I)

176

1. Increase ≥ 1 K-L grade

2. Decrease ≥ 1 mm of joint space

Average 8.4 years

Birn et al. [18]

Case-control

94 (5 cases, 89 controls)

Rapidly destructive OA: > 2 mm or > 50% JSN/year

NR

Birrell et al. [19]

Prospective cohort

195

Time to being put on a waiting list for THR

36 months

Bouyer et al. [20]

Prospective cohort (KHOALA)

242 (analyzed 133 patients)

1. Increase ≥ 1 K-L grade

2. Increase ≥ 1 JSN score

3. Time to THR

3 years

Castano Betancourt et al. [21]

Prospective cohort (GOAL)

189

JSN ≥ 20% compared to baseline or THR

2 years

Chaganti et al. [22]

Nested case-control (SOF)

168 cases and 173 controls

Decrease in MJS of 0.5 mm, increase of ≥ 1 in summary grade, increase ≥ 2 in total osteophyte score, or THR for OA

Average 8.3 years

Chevalier et al. [23]

Prospective cohort

30

Rapid evolution: JSN > 0.6 mm/year

1 year

Conrozier et al. [24]

Case-control

104 (analyzed 10 cases, 23 controls)

Rapidly progressive hip OA: severe hip pain, symptom onset within the last 2 years, annual rate of JSN > 1 mm, ESR < 20 mm/h, absence of detectable inflammatory or crystal-induced joint disease

NR

Conrozier et al. [25]

Retrospective cohort

89

Radiographic: YMN, calculated from MJS in mm/year

18–300 months

Conrozier et al. [26]

Prospective cohort

48

JSN in mm/year

1 year

Danielsson [27, 28]

Prospective cohort

168

1. Increase in pain index 0–5

2. Operation because of hip OA

3. Increase in radiographic index 0–10

8–12 years

van Dijk et al. [29]

Prospective cohort

123

1. Decrease in WOMAC function

2. Increase in seconds of timed walking test

3 years

van Dijk et al. [30]

Prospective cohort

123

1. Decrease in WOMAC function

2. Increase in seconds of timed walking test

3 years

Dorleijn et al. [31]

Prospective cohort (GOAL)

222 (analyzed 111 patients)

VAS score for pain, group highly progressive compared to mild pain groups based on LCGA

2 years

Dougados et al. [32]

Prospective cohort (ECHODIAH)

508 (analyzed 461 patients)

Radiological: ≥ 0.6 mm decrease in JSW

1 year

Dougados et al. [33]

Prospective cohort (ECHODIAH)

508 (analyzed 463 patients)

Radiological: > 0.5 mm decrease in JSW

2 years

Dougados et al. [34]

Prospective cohort

508

Time to the requirement of THR

3 years

Fukushima et al. [35]

Prospective cohort

20

Increase in Tönnis grade

25 months

Golightly et al. [36]

Prospective cohort (Johnston County)

1453

Increase in K-L grade or increase in hip symptoms (mild, moderate, severe)

3–13 years

Gossec et al. [37]

Prospective cohort

741 (analyzed 505 patients)

THR

2 years

Hartofilakidis et al. [38]

Retrospective cohort

210

THR

2 to > 10 years

Hawker et al. [39]

Prospective cohort

2128

Time to THR

6.1 years

Hoeven et al. [40]

Prospective cohort (Rotterdam I)

5650 (number analyzed: NR)

Increase ≥ 1 K-L grade baseline to follow-up

10 years

Holla et al. [41]

Prospective cohort (CHECK)

588

Moving into a higher group (quintiles of WOMAC-PF 0–68) or remaining within the three highest groups

2 years

Juhakoski et al. [42]

Prospective cohort

118

1. WOMAC pain (0–100)

2. WOMAC function (0–100)

2 years

Kalyoncu et al. [43]

Retrolective cohort (ECHODIAH)

192

THR

10 years

Kelman et al. [44]

Nested case-control (SOF)

396 (cases 197, controls 199)

Decrease in minimum joint space of ≥ 0.5 mm, an increase of ≥ 1 in the summary grade, an increase of ≥ 2 in total osteophyte score, or THR

8.3 years

Kerkhof et al. [45]

Prospective cohort (Rotterdam I)

1610

Radiologic: JSN ≤ 1.0 mm or THR during follow-up

NR

Kopec et al. [46]

Prospective cohort (Johnston County)

1590 (analyzed 571 people)

Increase ≥ 1 in K-L grade

3–13 years

Lane et al. [47]

Prospective cohort (SOF)

745

Decrease in minimum joint space of ≥ 0.5 mm, an increase of ≥ 1 in the summary grade, an increase of ≥ 2 in total osteophyte score, or THR

8 years

Lane et al. [48]

Nested case-control (SOF)

342

Radiological: decrease in minimum joint space of ≥ 0.5 mm, an increase of ≥ 1 in the summary grade, an increase of ≥ 2 in total osteophyte score, or THR

8.3 years

Laslett et al. [49]

Prospective cohort (TasOAC)

1099 (analyzed 765 people)

WOMAC pain (0–100)

2–4 years

Ledingham 1993 [50]

Prospective cohort

136

1. Global assessment of radiographic change

2. THR

3–73 months

Lievense et al. [51]

Prospective cohort

224 (analyzed 163 patients)

THR

5.8 years

Maillefert et al. [52]

Prospective cohort (ECHODIAH)

508

1. Decrease in JSW > 50% during the first year follow-up

2. THR in 1–5 years of follow-up

5 years

Mazieres et al. [53]

Prospective cohort (ECHODIAH)

507 (analyzed 333 patients)

JSN ≥ 0.5 mm or THP

3 years

Nelson et al. [54]

Prospective cohort (Johnston County)

309

1. Increase in K-L grade

2. Increase in osteophyte severity grade

3. Increase in JSN severity grade

5 years

Perry et al. [55]

Case-control

44

Radiographic: progressive deterioration

5–14 years

Peters et al. [56]

Prospective cohort

587 (analyzed 214 patients)

New Zealand score 0–80 (combination of pain and function)

7 years

Pisters et al. [57]

Prospective cohort

149

Increase in WOMAC function on average over time (measured at 1, 2, 3, 5 years)

5 years

Pollard 201et al. 2 [58]

Prospective cohort

264

Signs on examination of hip OA or symptoms at baseline and signs and symptoms at follow-up

5 years

Reijman et al. [59]

Prospective cohort (Rotterdam I)

1235

JSN ≥ 1.0 mm in at least 1 of 3 compartments (lateral, superior, axial)

6.6 years

Reijman et al. [60]

Prospective cohort (Rotterdam I)

1904

Radiologic: JSN ≤ 1.0 mm or THR during follow-up

6.6 years

Reijman et al. [61]

Prospective cohort (Rotterdam I)

1676

1. JSN of ≥ 1 mm

2. JSN of ≥ 1.5 mm

3. Increase of ≥ 1 K-L grade

6.6 years

Solignac [62]

Prospective cohort (ECHODIAH)

507 (analyzed 333 patients)

JSN ≥ 0.5 mm or THP

3 years

van Spil et al. [63]

Prospective cohort (CHECK)

1002 (analyzed 178 patients)

Radiographic: ≥ 1 K-L grade increase

5 years

Thompson et al. [64]

Case-control

34 cases, controls: NR

Rapidly progressive OA: loss of bone or a combined loss of bone and articular cartilage at rate > 5 mm per year

18 months

Tron et al. [65]

Retrospective cohort

39

Mean annual JSN in mm

NR

Verkleij et al. [66]

Prospective cohort (GOAL)

222 (analyzed 111 patients)

VAS score for pain, group highly progressive compared to mild pain, groups based on LCGA

2 years

Vinciguerra et al. [67]

Retrospective cohort

149

Time to THR

Variable

  1. NR not reported, OA osteoarthritis THR total hip replacement, K-L grade Kellgren and Lawrence grade, MJS minimum joint space, JSN joint space narrowing, JSW joint space width, YMN yearly mean narrowing, LCGA latent class growth analysis, ESR erythrocyte sedimentation rate, NRS numeric rating scale, VAS visual analog scale