From: Prognostic factors for progression of osteoarthritis of the hip: a systematic review
Prognostic factor | Studies | Associations | Best-evidence synthesis |
---|---|---|---|
Patient variables | |||
 No association | |||
  Body mass index | Strong evidence for no association | ||
 | No, no No, no, no, negative, positive | ||
  Female | Moderate evidence for no association | ||
 | No, positive, no No, no, no, no, no | ||
  Lower educational level | Moderate evidence for no association | ||
 | 1 low risk of bias cohort [16] 1 cohort [39] | No No | |
  Western or White ethnicity | Moderate evidence for no association | ||
 | 1 low risk of bias cohort [16] 1 cohort [39] | No No | |
  Alcohol consumption | Limited evidence for no association | ||
 | 1 low risk of bias cohort [16] | No | |
 Conflicting evidence | |||
  Higher age at baseline | Conflicting evidence | ||
 | No, positive,no No, positive$, no, no, positive | ||
Disease characteristics | |||
 Faster or more progression | |||
  Lower global assessment (self-reported) at baseline | Moderate evidence for faster or more progression | ||
 | 1 low risk of bias cohort [37] | Positive Positive, positive | |
  Previous use of NSAIDs | Limited evidence for more progression | ||
 | 1 low risk of bias cohort [37] | Positive | |
 No association | |||
  Longer duration of symptoms at baseline | Moderate evidence for no association | ||
 | 1 low risk of bias cohort [37] 1 cohort [19] | No No | |
  Having another disease (comorbidity) | Moderate evidence for no association | ||
 | 1 low risk of bias cohort [16] 1 cohort [39] | No No | |
  Morning stiffness | Moderate evidence for no association | ||
 | 1 low risk of bias cohort [16] 1 cohort [51] | No No | |
  Use of pain medication at baseline | Moderate evidence for no association | ||
 | 1 low risk of bias cohort [16] 1 cohort [19] | No No | |
  Presence of Heberden’s or Bouchard’s nodes | Moderate evidence for no association | ||
 | 1 low risk of bias cohort [16] | No No, no | |
  Previous intra-articular injection in the hip | Limited evidence for no association | ||
 | 1 low risk of bias cohort [37] | No | |
 Conflicting evidence | |||
  More limitations in physical function at baseline | Conflicting evidence | ||
 | Positive, positive, no No, no | ||
  More pain at baseline | Conflicting evidence | ||
 | Conflicted$$, positive, positive Positive, no, positive, no | ||
  Painful hip flexion (active or passive) | Conflicting evidence | ||
 | 1 low risk of bias cohort [16] 1 cohort [51] | Positive No | |
  Painful hip internal rotation (active or passive) | Conflicting evidence | ||
 | 1 low risk of bias cohort [16] 1 cohort [51] | Positive No | |
  Night pain at baseline | Conflicting evidence | ||
 | Positive, no | ||
  Limited range of motion of flexion of the hip | Conflicting evidence | ||
 | 1 low risk of bias cohort [16] | Positive Positive, no | |
  Limited range of motion of internal hip rotation | Conflicting evidence | ||
 | 1 low risk of bias cohort [16] | Positive Positive, no | |
  Limited range of motion of external hip rotation | Conflicting evidence | ||
 | Positive, no | ||
Chemical or imaging markers | |||
 Faster or more progression | |||
  Higher K-L grade at baseline | Strong evidence for more or faster progression | ||
 | 2 low risk of bias cohorts [34, 37] 1 cohorts [51] | Positive, positive Positive | |
  Superior or superolateral migration of the femoral head | Strong evidence for more or faster progression | ||
 | 2 low risk of bias cohorts [34, 47] 1 cohort [38] | Positive, positive Positive | |
  Subchondral sclerosis | Strong evidence for more progression | ||
 | Positive, positive | ||
  Statistical shape modeling | Moderate evidence that certain modes of SSM can predict progression | ||
 | Positive, positive, positive | ||
  Joint space narrowing at baseline | Moderate evidence for more or faster progression | ||
 | 1 low risk of bias cohort [16] 1 cohort [67] | Positive Positive | |
 No association | |||
  Cam-type deformity (alpha angle > 60°) | Limited evidence for no association | ||
 | 1 low risk of bias cohort [16] | No | |
 Conflicting evidence | |||
  Erythrocyte sedimentation rate | Conflicting evidence | ||
 | 1 low risk of bias cohort [16] 1 cohort [51] | Positive No | |
  Atrophic bone response (no osteophytes present) | Conflicting evidence | ||
 | 1 low risk of bias cohort [16] | Positive Positive, no | |
  Decrease in joint space width at baseline | Conflicting evidence | ||
 | 1 low risk of bias cohort [34] 1 cohort [51] | Positive No | |
  Wiberg’s center edge angle (CEA) | Conflicting evidence | ||
 | 1 low risk of bias cohort [16] 1 cohort [20] | Negative No |