Clinical features of central nervous system infections and experience in differential diagnosis from neuropsychiatric lupus erythematosus in a cohort of 8491 patients with systemic lupus erythematosus

Table 2 A multivariate logistic regression analysis of key points for discriminating CNS infections from NPSLE

Variables	P value	OR	95%CI
SLE disease duration^& ≥ 12 months	< 0.05	5.2	1.1–24.5
Pulse GCs*	0.070	7.7	0.8–70.7
Fever^§	< 0.001	34.3	5.2–226.7
CSF glucose ≤ 2.2 mmol/L^§	< 0.01	13.7	2.1–85.8
CSF PMN leukocytosis^§	< 0.05	1.10	1.00–1.19
Hypocomplementemia^§	< 0.01	0.08	0.02–0.41

CNS central nervous system, NPSLE neuropsychiatric lupus erythematosus, GCs glucocorticoids, CSF cerebrospinal fluid, PMN polymorphonuclear leukocyte
^&Disease duration from SLE diagnosis to CNS infections or NPSLE onset
*Evaluated medical history before the diagnosis of CNS infection or NPSLE
^§Evaluated within 2 weeks of CNS infection or NPSLE onset
Significant p values are shown in bold typeface

ISSN: 1478-6362