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Table 3 Simplified scoring system for distinguishing CNS infections from NPSLE

From: Clinical features of central nervous system infections and experience in differential diagnosis from neuropsychiatric lupus erythematosus in a cohort of 8491 patients with systemic lupus erythematosus

Item Score
Disease duration& ≥ 12 months 1
Fever§ 1
Intracranial pressure ≥ 300 mmH2O§ 1
WBCs in CSF ≥ 20/μL§ 1
PMN ratio in CSF ≥ 0.5%§ 1
Protein level in CSF ≥ 0.905 g/L§ 1
Glucose level in CSF ≤ 2.2 mmol/L§ 1
Absence of hypocomplementemia 1
Total 8
  1. CNS central nervous system, NPSLE neuropsychiatric lupus erythematosus, CSF cerebrospinal fluid, PMN polymorphonuclear leukocyte
  2. &Disease duration from SLE diagnosis to CNS infections or NPSLE onset
  3. §Evaluated within 2 weeks of CNS infection or NPSLE onset