Fig. 2

Inhibition of inflammatory cell infiltration into the vascular wall by the abrogation of LPA₁. a, b C57/BL6 WT and LPA₁-deficient mice were injected intraperitoneally with CAWS. The hearts of WT and LPA₁-deficient mice (n = 10, each) were stained with H&E (a). Representative photomicrographs are shown. The vasculitis scores of WT and LPA₁-deficient mice were evaluated (b). c, d C57/BL6 mice were injected intraperitoneally with CAWS from days 0 to 5. LA-01 (0, 60, 200 mg/kg/day; n = 10, each) was administered twice daily from days 0 to 28. On day 28, the hearts of mice were stained with H&E (c). Representative photomicrographs are shown. The vasculitis score was evaluated (d). Original magnification: × 40 (a, c). Data are the mean ± SEM. *P < 0.05 vs WT mice or vehicle (b, d)