Fig. 13From: Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damageCurcumin suppresses the protein levels of MSU-induced COX-2, TLR4, MyD88, and NLRP3 in the footpad tissue of mice with MSU-induced arthritis. a Total protein was examined by immunoblotting for the protein level of COX-2. b Total protein was examined by immunoblotting for the protein levels of TLR4, MyD88, and NLRP3. c, d, e, f Densitometry analysis of TLR4, MyD88, and NLRP3. The data are expressed as the mean ± SEM of four mice per group. #Significantly different from vehicle (Veh) alone, P < 0.05. *Significantly different from MSU alone, P < 0.05Back to article page