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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage

Fig. 5

Curcumin blocks the expression levels of TLR4, MyD88, and NLRP3 in the MSU-induced THP-1 cells. a The relative mRNA expression of TLR4, MyD88, and NLRP3 in the MSU-stimulated THP-1 cells pretreated with curcumin (n = 3, mean ± SEM). b Effects of curcumin on the MSU-stimulated protein levels of TLR4, MyD88, and NLRP3 in the MSU-stimulated THP-1 cells; the protein levels were determined by western blot analysis. c Densitometry analysis of TLR4, MyD88, and NLRP3 protein. The data are expressed as mean ± SEM for three experiments. #Significantly different from absence both MSU and curcumin. *Significantly different from absence of curcumin, P < 0.05

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Arthritis Research & Therapy

ISSN: 1478-6362

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